Linked Life Data

1555796

Source:http://linkedlifedata.com/resource/pubmed/id/1555796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-5-1
pubmed:abstractText
The photoirritant potential of topically applied chemicals was studied using guinea-pigs. Solutions of test chemicals were applied to the skin, and after 30 min the animals were irradiated with near-ultraviolet radiation. Skin reactions were assessed subjectively between 3 and 72 hr after the start of treatment. Acridine and anthracene caused immediate photoirritation, whereas reaction to 8-methoxy-psoralen (8-MOP) was delayed; acridine was weakly active compared with the strong photoirritancy of anthracene and 8-MOP. Ethanol and a mixture of dimethylacetamide-acetone-ethanol (DAE) were satisfactory solvents, and a time interval of 15 to 30 min between application and irradiation was optimal. It is concluded that animal tests should not be recommended if ingredients have negligible absorption of sunlight. The safety hazard of ingredients absorbing near-ultraviolet and visible radiation may be assessed by laboratory animal procedures to satisfy governmental regulations. The use of guinea-pigs allows the study to act as a preliminary test for the selection of non-photoirritant concentrations for photoallergy testing and reduction of animal numbers. The risk to consumers of photoactive products may be properly assessed by human studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0278-6915
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-60
pubmed:dateRevised
2006-3-13
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Phototoxicity testing in guinea-pigs.
pubmed:affiliation
Environmental Safety Laboratory, Unilever Research, Colworth House, Sharnbrook, Bedford, UK.
pubmed:publicationType
Journal Article