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rdf:type |
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lifeskim:mentions |
umls-concept:C0006826,
umls-concept:C0018017,
umls-concept:C0026336,
umls-concept:C0038952,
umls-concept:C0040808,
umls-concept:C0178602,
umls-concept:C0596087,
umls-concept:C0814225,
umls-concept:C0871261,
umls-concept:C1522424,
umls-concept:C1571702,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
5
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pubmed:dateCreated |
2005-2-9
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pubmed:abstractText |
A transgenic mouse model has revealed parameters of the angiogenic switch during multistep tumorigenesis of pancreatic islets, and demonstrated efficacy of antiangiogenic therapies. Pericytes have been revealed as functionally important for tumor neovasculature, using kinase inhibitors targeting their platelet-derived growth factor receptors (PDGFRs). Additionally, vascular endothelial growth factor receptor (VEGFR) inhibitors and metronomic chemotherapy show modest benefit against early- but not late-stage disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial...,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib,
http://linkedlifedata.com/resource/pubmed/chemical/sunitinib
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0732-183X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
939-52
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15557593-Adenoma, Islet Cell,
pubmed-meshheading:15557593-Angiogenesis Inhibitors,
pubmed-meshheading:15557593-Animals,
pubmed-meshheading:15557593-Antineoplastic Agents,
pubmed-meshheading:15557593-Antineoplastic Agents, Alkylating,
pubmed-meshheading:15557593-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15557593-Apoptosis,
pubmed-meshheading:15557593-Clinical Protocols,
pubmed-meshheading:15557593-Cyclophosphamide,
pubmed-meshheading:15557593-Disease Models, Animal,
pubmed-meshheading:15557593-Endothelial Cells,
pubmed-meshheading:15557593-Indoles,
pubmed-meshheading:15557593-Mice,
pubmed-meshheading:15557593-Mice, Transgenic,
pubmed-meshheading:15557593-Neovascularization, Pathologic,
pubmed-meshheading:15557593-Pancreatic Neoplasms,
pubmed-meshheading:15557593-Pericytes,
pubmed-meshheading:15557593-Piperazines,
pubmed-meshheading:15557593-Protein Kinase Inhibitors,
pubmed-meshheading:15557593-Protein-Tyrosine Kinases,
pubmed-meshheading:15557593-Pyrimidines,
pubmed-meshheading:15557593-Pyrroles,
pubmed-meshheading:15557593-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:15557593-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:15557593-Remission Induction
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pubmed:year |
2005
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pubmed:articleTitle |
A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer.
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pubmed:affiliation |
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California San Francisco, 513 Parnassas Avenue, San Francisco, CA 94143, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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