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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-11-23
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pubmed:abstractText |
Complement receptor 2-deficient (Cr2(-/-)) mice are resistant to mesenteric ischemia/reperfusion (I/R) injury because they lack a component of the natural Ab repertoire. Neither the nature of the Abs that are involved in I/R injury nor the composition of the target Ag, to which recognition is lacking in Cr2(-/-) mice, is known. Because anti-phospholipid Abs have been shown to mediate fetal growth retardation and loss when injected into pregnant mice, we performed experiments to determine whether anti-phospholipid Abs can also reconstitute I/R injury and, therefore, represent members of the injury-inducing repertoire that is missing in Cr2(-/-) mice. We demonstrate that both murine and human monoclonal and polyclonal Abs against negatively charged phospholipids can reconstitute mesenteric I/R-induced intestinal and lung tissue damage in Cr2(-/-) mice. In addition, Abs against beta2 glycoprotein I restore local and remote tissue damage in the Cr2(-/-) mice. Unlike Cr2(-/-) mice, reconstitution of I/R tissue damage in the injury-resistant Rag-1(-/-) mouse required the infusion of both anti-beta2-glycoprotein I and anti-phospholipid Ab. We conclude that anti-phospholipid Abs can bind to tissues subjected to I/R insult and mediate tissue damage.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anticardiolipin,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Antiphospholipid,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immune Sera,
http://linkedlifedata.com/resource/pubmed/chemical/RAG-1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Complement 3b,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Complement 3d,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Glycoprotein I
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7055-61
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15557203-Animals,
pubmed-meshheading:15557203-Antibodies, Anticardiolipin,
pubmed-meshheading:15557203-Antibodies, Antiphospholipid,
pubmed-meshheading:15557203-Antibodies, Monoclonal,
pubmed-meshheading:15557203-Female,
pubmed-meshheading:15557203-Glycoproteins,
pubmed-meshheading:15557203-Homeodomain Proteins,
pubmed-meshheading:15557203-Humans,
pubmed-meshheading:15557203-Immune Sera,
pubmed-meshheading:15557203-Infusions, Intravenous,
pubmed-meshheading:15557203-Intestinal Mucosa,
pubmed-meshheading:15557203-Lung,
pubmed-meshheading:15557203-Male,
pubmed-meshheading:15557203-Mesenteric Arteries,
pubmed-meshheading:15557203-Mice,
pubmed-meshheading:15557203-Mice, Knockout,
pubmed-meshheading:15557203-Receptors, Complement 3b,
pubmed-meshheading:15557203-Receptors, Complement 3d,
pubmed-meshheading:15557203-Reperfusion Injury,
pubmed-meshheading:15557203-beta 2-Glycoprotein I
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pubmed:year |
2004
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pubmed:articleTitle |
Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice.
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pubmed:affiliation |
Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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