Source:http://linkedlifedata.com/resource/pubmed/id/15557160
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2004-11-23
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| pubmed:abstractText |
The chemokine receptor CCR7 is a key factor in the coordinate migration of T cells and dendritic cells (DC) into and their localization within secondary lymphoid organs. In this study we investigated the impact of CCR7 on CD8(+) T cell responses by infecting CCR7(-/-) mice with lymphocytic choriomeningitis virus (LCMV). We found that the absence of CCR7 affects the magnitude of an antiviral CTL response during the acute phase, with reduced numbers of virus-specific CTL in all lymphoid and nonlymphoid organs tested. On the single cell level, CCR7-deficient CTL gained full effector function, such that antiviral protection in CCR7-deficient mice was complete, but delayed. Similarly, adoptive transfer experiments using DC from CCR7-deficient or competent mice for the priming of CCR7-positive or CCR7-negative CD8(+) T cells, respectively, revealed that ectopic positioning of DC and CTL outside organized T cell zones results in reduced priming efficacy. In the memory phase, CCR7-deficient mice maintained a stable LCMV-specific CTL population, predominantly in nonlymphoid organs, and rapidly mounted protective CTL responses against a challenge infection with a vaccinia virus recombinant for the gp33 epitope of LCMV. Taken together, the CCR7-dependent organization of the T cell zone does not appear to be a prerequisite for antiviral effector CTL differentiation and the sustenance of antiviral memory responses in lymphoid or peripheral tissues.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
173
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6684-93
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15557160-Adoptive Transfer,
pubmed-meshheading:15557160-Animals,
pubmed-meshheading:15557160-Cell Movement,
pubmed-meshheading:15557160-Clonal Deletion,
pubmed-meshheading:15557160-Cytotoxicity, Immunologic,
pubmed-meshheading:15557160-Dendritic Cells,
pubmed-meshheading:15557160-Immunization, Secondary,
pubmed-meshheading:15557160-Immunologic Memory,
pubmed-meshheading:15557160-Kinetics,
pubmed-meshheading:15557160-L-Selectin,
pubmed-meshheading:15557160-Lymphocyte Activation,
pubmed-meshheading:15557160-Lymphocytic Choriomeningitis,
pubmed-meshheading:15557160-Lymphocytic choriomeningitis virus,
pubmed-meshheading:15557160-Lymphoid Tissue,
pubmed-meshheading:15557160-Mice,
pubmed-meshheading:15557160-Mice, Inbred C57BL,
pubmed-meshheading:15557160-Mice, Knockout,
pubmed-meshheading:15557160-Mice, Transgenic,
pubmed-meshheading:15557160-Organ Specificity,
pubmed-meshheading:15557160-Receptors, CCR7,
pubmed-meshheading:15557160-Receptors, Chemokine,
pubmed-meshheading:15557160-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:15557160-T-Lymphocytes, Regulatory
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Impact of CCR7 on priming and distribution of antiviral effector and memory CTL.
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| pubmed:affiliation |
Institute of Experimental Immunology, Zurich, Switzerland. tobias.junt@usz.ch
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| pubmed:publicationType |
Journal Article,
Comparative Study
|