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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-11-23
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pubmed:abstractText |
IL-15 is critical for generation of multiple lymphoid subsets. Recent data have demonstrated a unique aspect of responses to IL-15, in that cells bearing the IL-15Ralpha chain can bind soluble IL-15 and "transpresent" the cytokine to other cells, allowing the latter to respond to IL-15. However, it is unclear whether IL-15 is normally secreted and then becomes bound to surface IL-15Ralpha on bystander cells, or whether transpresentation is mediated by the same cells which synthesize IL-15. Using mixed bone marrow chimeric mice, we present evidence for the latter model, showing that development of NK cells and memory phenotype CD8 T cells necessitates that both IL-15 and IL-15Ralpha be expressed by the same population of cells. These data argue that soluble forms of IL-15 are irrelevant for physiological responses to this cytokine, and the implications of this finding are discussed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6537-41
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15557143-Animals,
pubmed-meshheading:15557143-Bone Marrow Cells,
pubmed-meshheading:15557143-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15557143-Cell Differentiation,
pubmed-meshheading:15557143-Cells, Cultured,
pubmed-meshheading:15557143-Cross-Priming,
pubmed-meshheading:15557143-Epitopes, T-Lymphocyte,
pubmed-meshheading:15557143-Homeostasis,
pubmed-meshheading:15557143-Immunologic Memory,
pubmed-meshheading:15557143-Interleukin-15,
pubmed-meshheading:15557143-Killer Cells, Natural,
pubmed-meshheading:15557143-Lymphopenia,
pubmed-meshheading:15557143-Mice,
pubmed-meshheading:15557143-Mice, Inbred C57BL,
pubmed-meshheading:15557143-Mice, Knockout,
pubmed-meshheading:15557143-Mice, Transgenic,
pubmed-meshheading:15557143-Models, Immunological,
pubmed-meshheading:15557143-Protein Subunits,
pubmed-meshheading:15557143-Radiation Chimera,
pubmed-meshheading:15557143-Receptors, Interleukin-15,
pubmed-meshheading:15557143-Receptors, Interleukin-2
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pubmed:year |
2004
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pubmed:articleTitle |
Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells.
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pubmed:affiliation |
Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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