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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-11-23
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pubmed:abstractText |
Hypoxia elicits a wide range of responses that occur at different organizational levels in the body. Hypoxia is not only a signal for energy conservation and metabolic change, but triggers expression of a select set of genes. The transcription factor hypoxia-inducible factor 1 (HIF-1) is now appreciated to be a master factor of the gene induction. Although knowledge on molecular mechanisms of HIF-1 activation in response to hypoxia is accumulating, the molecular mechanism of maintenance of HIF-1 activity under normoxic conditions remains to be elucidated. We demonstrate that the intravenous anesthetic propofol reversibly inhibits HIF-1 activity and the gene expression mediated by HIF-1 by blocking the synthesis of the HIF-1alpha subunit under 20% or 5% O2 conditions, but not under 1% O2 conditions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Intravenous,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Propofol,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
577
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
434-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15556623-Anesthetics, Intravenous,
pubmed-meshheading:15556623-Antibodies, Monoclonal,
pubmed-meshheading:15556623-Cell Hypoxia,
pubmed-meshheading:15556623-Cell Line,
pubmed-meshheading:15556623-DNA-Binding Proteins,
pubmed-meshheading:15556623-Dose-Response Relationship, Drug,
pubmed-meshheading:15556623-Endothelium, Vascular,
pubmed-meshheading:15556623-Gene Expression Regulation,
pubmed-meshheading:15556623-Genes, Reporter,
pubmed-meshheading:15556623-Glutathione Transferase,
pubmed-meshheading:15556623-Humans,
pubmed-meshheading:15556623-Hypoxia-Inducible Factor 1,
pubmed-meshheading:15556623-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:15556623-Immunoblotting,
pubmed-meshheading:15556623-Kinetics,
pubmed-meshheading:15556623-Luciferases,
pubmed-meshheading:15556623-Nuclear Proteins,
pubmed-meshheading:15556623-Oxygen,
pubmed-meshheading:15556623-Plasmids,
pubmed-meshheading:15556623-Propofol,
pubmed-meshheading:15556623-Recombinant Fusion Proteins,
pubmed-meshheading:15556623-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15556623-Transcription Factors,
pubmed-meshheading:15556623-Transcriptional Activation,
pubmed-meshheading:15556623-Umbilical Veins
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pubmed:year |
2004
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pubmed:articleTitle |
The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner.
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pubmed:affiliation |
Department of Anesthesia, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20, Ohgimachi, Kita-ku, Osaka 530-8480, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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