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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-11-23
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pubmed:abstractText |
Snail, a zinc-finger transcriptional repressor, is essential for mesoderm and neural crest cell formation and epithelial-mesenchymal transition. The basic helix-loop-helix transcription factors E2A and Twist have been linked with Snail during embryonic development. In this study, we examined the role of Snail in cellular differentiation through regulation of p21(WAF/CIP1) expression. A reporter assay with the p21 promoter demonstrated that Snail inhibited expression of p21 induced by E2A. Co-expression of Snail with Twist showed additive inhibitory effects. Deletion mutants of the p21 promoter revealed that sequences between -270 and -264, which formed a complex with unidentified nuclear factor(s), were critical for E2A and Snail function. The E2A-dependent expression of the endogenous p21 gene was also inhibited by Snail.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TCF3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TWIST1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Twist Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/snail family transcription factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
325
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1136-44
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15555546-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:15555546-Cell Cycle Proteins,
pubmed-meshheading:15555546-Cell Differentiation,
pubmed-meshheading:15555546-Cell Line,
pubmed-meshheading:15555546-Cells, Cultured,
pubmed-meshheading:15555546-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:15555546-DNA-Binding Proteins,
pubmed-meshheading:15555546-Fibroblasts,
pubmed-meshheading:15555546-Gene Expression Regulation,
pubmed-meshheading:15555546-Humans,
pubmed-meshheading:15555546-Nuclear Proteins,
pubmed-meshheading:15555546-Osteoblasts,
pubmed-meshheading:15555546-Recombinant Proteins,
pubmed-meshheading:15555546-Repressor Proteins,
pubmed-meshheading:15555546-Transcription Factors,
pubmed-meshheading:15555546-Twist Transcription Factor
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pubmed:year |
2004
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pubmed:articleTitle |
Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist.
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pubmed:affiliation |
Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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