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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-11-19
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pubmed:abstractText |
We investigated the in vivo anti-tumor effect of intratumoral administration of dendritic cells (DCs) after chemotherapy using TS-1, and followed by immunopotentiator OK-432. Both in Meth-A-bearing BALB/c and in SCCV II-bearing C3H/HeN mice, one week of oral administration of TS-1 affected a partial eradication of established tumors. TS-1 followed by DCs and OK-432 resulted in a marked inhibition in tumor growth, and also contributed to a greater prolongation of survival. Cytotoxic activities of tumor-infiltrating lymphocytes and draining lymph node cells against inoculated tumor cells were significantly increased by the therapy. Cytotoxic memory T cells were also induced. The same therapy was also applied to SCCV II-bearing C3H/HeJ mice in which the Toll-like receptor (TLR) 4 is mutated; no immunotherapeutic effect was observed in the mice. These findings suggest that local DC therapy in combination with TS-1 and OK-432 may well be a useful strategy for the treatment of solid tumors, and that TLR4 signaling is involved in the success of this therapy.
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pubmed:language |
jpn
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Picibanil,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/S 1 (combination),
http://linkedlifedata.com/resource/pubmed/chemical/Tegafur,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0385-0684
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1627-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15553665-Animals,
pubmed-meshheading:15553665-Antimetabolites, Antineoplastic,
pubmed-meshheading:15553665-Antineoplastic Agents,
pubmed-meshheading:15553665-Dendritic Cells,
pubmed-meshheading:15553665-Drug Combinations,
pubmed-meshheading:15553665-Membrane Glycoproteins,
pubmed-meshheading:15553665-Mice,
pubmed-meshheading:15553665-Mice, Inbred BALB C,
pubmed-meshheading:15553665-Mice, Inbred C3H,
pubmed-meshheading:15553665-Neoplasms, Experimental,
pubmed-meshheading:15553665-Oxonic Acid,
pubmed-meshheading:15553665-Picibanil,
pubmed-meshheading:15553665-Pyridines,
pubmed-meshheading:15553665-Receptors, Cell Surface,
pubmed-meshheading:15553665-Sarcoma, Experimental,
pubmed-meshheading:15553665-Tegafur,
pubmed-meshheading:15553665-Toll-Like Receptor 4,
pubmed-meshheading:15553665-Toll-Like Receptors
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pubmed:year |
2004
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pubmed:articleTitle |
[Anti-tumor effect of intratumoral administration of dendritic cells in combination with TS-1 and OK-432].
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pubmed:affiliation |
Second Dept. of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry.
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pubmed:publicationType |
Journal Article,
English Abstract
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