Source:http://linkedlifedata.com/resource/pubmed/id/15551344
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2005-2-15
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| pubmed:abstractText |
Interleukin-1B and IL-1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL-1B-511T polymorphism and the risk of GC in Asians. We tested for an association between IL-1 loci polymorphisms with increased gastric mucosal levels of IL-1beta and an increased risk of developing GC in a Korean population. Polymorphisms of IL-1A-889, IL-1B-31, IL-1B-511 and IL-1RN were genotyped in 434 controls and 234 patients with GC. Mucosal IL-1beta cytokine was measured using an ELISA. The frequencies of IL-1A, IL-1B-511, IL-1B-31 and IL-1RN were not statistically different between controls and all patients with GC. After subclassification of GC, only patients with intestinal-type GC showed a higher frequency of IL-1B-31T homozygotes (OR = 2.2; 95% CI = 1.1-4.3) compared with controls. Risk was also significantly increased in these patients for IL-1B-31T homozygotes compared with patients with diffuse-type GC (OR = 3.4; 95% CI = 1.5-7.7). As in Caucasian populations, linkage disequilibrium between IL-1B-31 and IL-1B-511 was nearly complete, but the pattern of haplotype related to the risk of GC (IL-1B-31T/IL-1B-511C) was opposite (IL-1B-511T/IL-1B-31C). Mucosal IL-1beta levels in H. pylori-infected GC patients were higher in patients homozygous for IL-1B-31T compared with IL-1B-31C/T and IL-1B-31C/C. Thus, the combined effects of H. pylori infection and IL-1B-31T/IL-1B-511C polymorphisms with enhanced mucosal IL-1beta production contributed to the development of intestinal-type GC in this Korean population.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
0020-7136
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| pubmed:author |
pubmed-author:ChangRinR,
pubmed-author:ChangYoung-WoonYW,
pubmed-author:DongSeok-HoSH,
pubmed-author:JangJae-YoungJY,
pubmed-author:JungWoon WonWW,
pubmed-author:KimByung-HoBH,
pubmed-author:KimHyo-JongHJ,
pubmed-author:KimNam-HoonNH,
pubmed-author:LeeHyo JungHJ,
pubmed-author:LeeJae WonJW,
pubmed-author:LeeJoung-IlJI
|
| pubmed:copyrightInfo |
(c) 2004 Wiley-Liss, Inc.
|
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
114
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
465-71
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| pubmed:dateRevised |
2007-7-24
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| pubmed:meshHeading |
pubmed-meshheading:15551344-Adult,
pubmed-meshheading:15551344-Aged,
pubmed-meshheading:15551344-Case-Control Studies,
pubmed-meshheading:15551344-Female,
pubmed-meshheading:15551344-Gastric Mucosa,
pubmed-meshheading:15551344-Genotype,
pubmed-meshheading:15551344-Helicobacter Infections,
pubmed-meshheading:15551344-Helicobacter pylori,
pubmed-meshheading:15551344-Humans,
pubmed-meshheading:15551344-Interleukin-1,
pubmed-meshheading:15551344-Korea,
pubmed-meshheading:15551344-Linkage Disequilibrium,
pubmed-meshheading:15551344-Male,
pubmed-meshheading:15551344-Middle Aged,
pubmed-meshheading:15551344-Polymorphism, Genetic,
pubmed-meshheading:15551344-Receptors, Interleukin-1,
pubmed-meshheading:15551344-Risk Factors,
pubmed-meshheading:15551344-Stomach Neoplasms
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| pubmed:year |
2005
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| pubmed:articleTitle |
Interleukin-1B (IL-1B) polymorphisms and gastric mucosal levels of IL-1beta cytokine in Korean patients with gastric cancer.
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| pubmed:affiliation |
Department of Gastroenterology, Kyung Hee University College of Medicine, Seoul, South Korea. cywgi@chollian.net
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| pubmed:publicationType |
Journal Article
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