Linked Life Data

15548228

Source:http://linkedlifedata.com/resource/pubmed/id/15548228

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-11-19
pubmed:abstractText
Neuroadaptive changes underlying repeated exposure to cocaine-induced behavioural sensitization have been related to modification in the pattern of synaptic connectivity and excitatory transmission. Remarkably, even a single exposure to abused drugs is sufficient to elicit lasting behavioural sensitization. The present study investigated whether in Sprague-Dawley rats a single, behavioural sensitizing dose of cocaine is sufficient to induce changes in the mRNA levels of growth-associated protein 43 (GAP-43), an important protein in mediating experience-dependent plasticity and synaptic reorganization, and of glutamate receptor 1 (GluR1), a subunit of AMPA glutamate receptors, a protein that is up-regulated with repeated cocaine. Single exposure to 20, but not 10 mg/kg cocaine induced locomotor sensitization to a second injection of 10 mg/kg cocaine, observed at 24 h, 48 h and 7 days. Single dose of 20 but not 10 mg/kg cocaine 48 h before scheduled death significantly enhanced GluR1 and GAP-43 mRNA expression in the nucleus accumbens (NAc), both shell and core subregions, and ventral tegmental area (VTA). No changes were found in the levels of mRNA for GluR1 and GAP-43 in the frontal cortex, caudate putamen, dentate gyrus of hippocampus and basolateral nucleus of the amygdala after the single dose of 20 mg/kg cocaine. These results further strengthen the involvement of NAc and VTA in the behavioural sensitization and suggest a role of GAP-43 in the synaptic reorganization associated to drug abuse.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0953-816X
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2833-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15548228-Animals, pubmed-meshheading:15548228-Behavior, Animal, pubmed-meshheading:15548228-Cell Count, pubmed-meshheading:15548228-Cocaine, pubmed-meshheading:15548228-Dopamine Uptake Inhibitors, pubmed-meshheading:15548228-Dose-Response Relationship, Drug, pubmed-meshheading:15548228-GAP-43 Protein, pubmed-meshheading:15548228-Gene Expression Regulation, pubmed-meshheading:15548228-In Situ Hybridization, pubmed-meshheading:15548228-Male, pubmed-meshheading:15548228-Motor Activity, pubmed-meshheading:15548228-Nucleus Accumbens, pubmed-meshheading:15548228-RNA, Messenger, pubmed-meshheading:15548228-Rats, pubmed-meshheading:15548228-Rats, Sprague-Dawley, pubmed-meshheading:15548228-Receptors, AMPA, pubmed-meshheading:15548228-Time Factors, pubmed-meshheading:15548228-Ventral Tegmental Area
pubmed:year
2004
pubmed:articleTitle
A single high dose of cocaine induces behavioural sensitization and modifies mRNA encoding GluR1 and GAP-43 in rats.
pubmed:affiliation
Istituto di Ricerche Farmacologiche 'Mario Negri' Via Eritrea 62, 20157 Milan, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't