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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2004-11-19
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pubmed:abstractText |
Resistance to antitumor agents is a major cause of treatment failure in patients with cancer. Some mechanisms of tumor resistance to cytotoxic drugs may involve increased acidification of extracellular compartments. We investigated whether proton pump inhibitors (PPIs), currently used in the anti-acid treatment of peptic disease, could inhibit the acidification of the tumor microenvironment and increase the sensitivity of tumor cells to cytotoxic agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1460-2105
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pubmed:author |
pubmed-author:AranciaGiuseppeG,
pubmed-author:BelardelliFilippoF,
pubmed-author:De MilitoAngeloA,
pubmed-author:FaisStefanoS,
pubmed-author:FedericiCristinaC,
pubmed-author:IessiElisabettaE,
pubmed-author:LogozziMariantoniaM,
pubmed-author:LozuponeFrancescoF,
pubmed-author:LucianiFrancescaF,
pubmed-author:LuginiLuanaL,
pubmed-author:MarraManuelaM,
pubmed-author:MolinariAgneseA,
pubmed-author:MontinaroAnnalisaA,
pubmed-author:ParmianiGiorgioG,
pubmed-author:RivoltiniLiciaL,
pubmed-author:SpadaMassimoM
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1702-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15547183-2-Pyridinylmethylsulfinylbenzimidazoles,
pubmed-meshheading:15547183-Adenocarcinoma,
pubmed-meshheading:15547183-Animals,
pubmed-meshheading:15547183-Antineoplastic Agents,
pubmed-meshheading:15547183-Benzimidazoles,
pubmed-meshheading:15547183-Blotting, Western,
pubmed-meshheading:15547183-Cell Line, Tumor,
pubmed-meshheading:15547183-Cisplatin,
pubmed-meshheading:15547183-Drug Resistance, Neoplasm,
pubmed-meshheading:15547183-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:15547183-Fluorouracil,
pubmed-meshheading:15547183-Humans,
pubmed-meshheading:15547183-Hydrogen-Ion Concentration,
pubmed-meshheading:15547183-Immunohistochemistry,
pubmed-meshheading:15547183-Inhibitory Concentration 50,
pubmed-meshheading:15547183-Lymphoma,
pubmed-meshheading:15547183-Melanoma,
pubmed-meshheading:15547183-Mice,
pubmed-meshheading:15547183-Mice, SCID,
pubmed-meshheading:15547183-Microscopy, Confocal,
pubmed-meshheading:15547183-Omeprazole,
pubmed-meshheading:15547183-Proton Pumps,
pubmed-meshheading:15547183-Sulfoxides,
pubmed-meshheading:15547183-Transplantation, Heterologous,
pubmed-meshheading:15547183-Vinblastine
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pubmed:year |
2004
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pubmed:articleTitle |
Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs.
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pubmed:affiliation |
Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Nazionale dei Tumori, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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