Source:http://linkedlifedata.com/resource/pubmed/id/15545978
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2005-3-30
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| pubmed:abstractText |
Schizophrenia is a common, multigenic psychiatric disorder. Linkage studies, including a recent meta-analysis of genome scans, have repeatedly implicated chromosome 8p12-p23.1 in schizophrenia susceptibility. More recently, significant association with a candidate gene on 8p12, neuregulin 1 (NRG1), has been reported in several European and Chinese samples. We investigated NRG1 for association in schizophrenia patients of Portuguese descent to determine whether this gene is a risk factor in this population. We tested NRG1 markers and haplotypes for association in 111 parent-proband trios, 321 unrelated cases, and 242 control individuals. Associations were found with a haplotype that overlaps the risk haplotype originally reported in the Icelandic population ("Hap(ICE)"), and two haplotypes located in the 3' end of NRG1 (all P<0.05). However, association was not detected with Hap(ICE) itself. Comparison of NRG1 transcript expression in peripheral leukocytes from schizophrenia patients and unaffected siblings identified 3.8-fold higher levels of the SMDF variant in patients (P=0.039). Significant positive correlations (P<0.001) were found between SMDF and HRG-beta 2 expression and between HRG-gamma and ndf43 expression, suggesting common transcriptional regulation of NRG1 variants. In summary, our results suggest that haplotypes across NRG1 and multiple NRG1 variants are involved in schizophrenia.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1359-4184
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| pubmed:author |
pubmed-author:AldingerK AKA,
pubmed-author:AzevedoM HMH,
pubmed-author:CarvalhoCC,
pubmed-author:DouradoAA,
pubmed-author:FerreiraC PCP,
pubmed-author:GaleA MAM,
pubmed-author:GentileK LKL,
pubmed-author:KirbyAA,
pubmed-author:MacedoAA,
pubmed-author:McGannLL,
pubmed-author:MedeirosH MHM,
pubmed-author:MiddletonF AFA,
pubmed-author:MorleyC PCP,
pubmed-author:NeisLL,
pubmed-author:PatoC NCN,
pubmed-author:PattersonN JNJ,
pubmed-author:PetryshenT LTL,
pubmed-author:PurcellSS,
pubmed-author:RockwellG NGN,
pubmed-author:SklarPP,
pubmed-author:TahlA RAR,
pubmed-author:ValensiQQ
|
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
366-74, 328
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:15545978-Chromosome Mapping,
pubmed-meshheading:15545978-Chromosomes, Human, Pair 8,
pubmed-meshheading:15545978-European Continental Ancestry Group,
pubmed-meshheading:15545978-Family,
pubmed-meshheading:15545978-Female,
pubmed-meshheading:15545978-Genetic Linkage,
pubmed-meshheading:15545978-Genetic Predisposition to Disease,
pubmed-meshheading:15545978-Genomics,
pubmed-meshheading:15545978-Haplotypes,
pubmed-meshheading:15545978-Humans,
pubmed-meshheading:15545978-Male,
pubmed-meshheading:15545978-Microsatellite Repeats,
pubmed-meshheading:15545978-Nerve Tissue Proteins,
pubmed-meshheading:15545978-Neuregulin-1,
pubmed-meshheading:15545978-Pedigree,
pubmed-meshheading:15545978-Polymorphism, Single Nucleotide,
pubmed-meshheading:15545978-Portugal,
pubmed-meshheading:15545978-Reference Values,
pubmed-meshheading:15545978-Schizophrenia
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Support for involvement of neuregulin 1 in schizophrenia pathophysiology.
|
| pubmed:affiliation |
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|