Source:http://linkedlifedata.com/resource/pubmed/id/15543342
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-11-15
|
| pubmed:abstractText |
Elevated plasma IL-6 levels have been implicated in the pathogenesis of coronary heart disease. We have investigated the association of two polymorphisms in the promoter of IL-6 (-572G>C and -174G>C) with levels of inflammatory markers and risk of myocardial infarction (MI) in a European study of MI survivors and age-matched controls from two high-risk centres in the North of Europe, and two low risk centres in the South. IL-6 and CRP levels were similar in controls in both regions, but were higher in cases. For the -174G>C polymorphism the rare -174C allele showed a regional difference in allele frequency, being more common in the North European group (0.43 vs 0.28; p < 0.0005), where -174C allele carriers showed an apparent reduced risk of MI compared to -174GG homozygotes (OR 0.53, 95%CI 0.32, 0.86). No such effect was observed in the South or with the -572G>C in either group. Neither genotype was associated with a significant effect on plasma IL-6 levels in either cases or controls. Furthermore, no regional difference was observed in the frequency of the -572G>C SNP, suggesting that these polymorphisms are unlikely to be contributing to the observed increased risk of cardiovascular disease in Northern Europe.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0340-6245
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| pubmed:author |
pubmed-author:AillaudM FMF,
pubmed-author:HIFMECH study group,
pubmed-author:HaweEE,
pubmed-author:HumphriesStephen ESE,
pubmed-author:Juhan-VagueIrèneI,
pubmed-author:KelbermanDanielD,
pubmed-author:LundmanPiaP,
pubmed-author:LuongL ALA,
pubmed-author:MargaglioneMaurizioM,
pubmed-author:Mohamed-AliVidyaV,
pubmed-author:TornvallPerP,
pubmed-author:TremoliElenaE,
pubmed-author:YudkinJohn SJS,
pubmed-author:di MinnoGiovanniG
|
| pubmed:issnType |
Print
|
| pubmed:volume |
92
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1122-8
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:15543342-Adult,
pubmed-meshheading:15543342-Biological Markers,
pubmed-meshheading:15543342-Case-Control Studies,
pubmed-meshheading:15543342-Europe,
pubmed-meshheading:15543342-Gene Frequency,
pubmed-meshheading:15543342-Genetic Predisposition to Disease,
pubmed-meshheading:15543342-Genotype,
pubmed-meshheading:15543342-Humans,
pubmed-meshheading:15543342-Inflammation,
pubmed-meshheading:15543342-Interleukin-6,
pubmed-meshheading:15543342-Male,
pubmed-meshheading:15543342-Middle Aged,
pubmed-meshheading:15543342-Molecular Epidemiology,
pubmed-meshheading:15543342-Myocardial Infarction,
pubmed-meshheading:15543342-Polymorphism, Single Nucleotide,
pubmed-meshheading:15543342-Promoter Regions, Genetic,
pubmed-meshheading:15543342-Risk Factors,
pubmed-meshheading:15543342-Survivors,
pubmed-meshheading:15543342-Topography, Medical
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. The HIFMECH Study.
|
| pubmed:affiliation |
Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|