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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2004-12-1
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pubmed:abstractText |
Gastrulation movements are critical for establishing the three principal germ layers and the basic architecture of vertebrate embryos. Although the individual molecules and pathways involved are not clearly understood, non-canonical Wnt signals are known to participate in developmental processes, including planar cell polarity and directed cell rearrangements. Here we demonstrate that the dual-specificity transcriptional repressor Kaiso, first identified in association with p120-catenin, is required for Xenopus gastrulation movements. In addition, depletion of xKaiso results in increased expression of the non-canonical xWnt11, which contributes to the xKaiso knockdown phenotype as it is significantly rescued by dominant-negative Wnt11. We further demonstrate that xWnt11 is a direct gene target of xKaiso and that p120-catenin association relieves xKaiso repression in vivo. Our results indicate that p120-catenin and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catenins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/XKaiso protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zbtb33 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/delta catenin,
http://linkedlifedata.com/resource/pubmed/chemical/wnt-11 protein, Xenopus
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1465-7392
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1212-20
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15543138-Animals,
pubmed-meshheading:15543138-Body Patterning,
pubmed-meshheading:15543138-Catenins,
pubmed-meshheading:15543138-Cell Adhesion Molecules,
pubmed-meshheading:15543138-Embryo, Nonmammalian,
pubmed-meshheading:15543138-Female,
pubmed-meshheading:15543138-Gastrula,
pubmed-meshheading:15543138-Gene Expression Regulation, Developmental,
pubmed-meshheading:15543138-Genes, Regulator,
pubmed-meshheading:15543138-Glycoproteins,
pubmed-meshheading:15543138-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:15543138-Oligonucleotides, Antisense,
pubmed-meshheading:15543138-Phenotype,
pubmed-meshheading:15543138-Phosphoproteins,
pubmed-meshheading:15543138-RNA, Messenger,
pubmed-meshheading:15543138-Repressor Proteins,
pubmed-meshheading:15543138-Signal Transduction,
pubmed-meshheading:15543138-Transcription Factors,
pubmed-meshheading:15543138-Up-Regulation,
pubmed-meshheading:15543138-Wnt Proteins,
pubmed-meshheading:15543138-Xenopus Proteins,
pubmed-meshheading:15543138-Xenopus laevis
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pubmed:year |
2004
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pubmed:articleTitle |
Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, The University of Texas Graduate School of Biomedical Science, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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