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rdf:type |
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lifeskim:mentions |
umls-concept:C0002708,
umls-concept:C0025991,
umls-concept:C0027882,
umls-concept:C0036751,
umls-concept:C0175392,
umls-concept:C0442805,
umls-concept:C0521119,
umls-concept:C0969397,
umls-concept:C1515877,
umls-concept:C1540159,
umls-concept:C1879547
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pubmed:issue |
3
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pubmed:dateCreated |
2004-11-15
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pubmed:abstractText |
The intra dorsal raphe nucleus (DRN) administration of corticotropin releasing hormone (CRF) inhibits serotonergic (5-HT) activity in this structure, an effect blocked by antagonists selective for the type 1 CRF receptor (CRF1). The DRN has a high density of the type 2 receptor (CRF2), and so the present experiments explored the impact of CRF2 activation within the DRN on 5-HT function. The intra-DRN administration of the selective CRF2 agonist urocortin 2 (Ucn 2) dose dependently increased 5-HT efflux in the basolateral amygdala, a projection region of the DRN. Intra-DRN Ucn 2 also increased c-fos expression in labeled 5-HT neurons. Both of these effects of Ucn 2 were completely blocked by intra-DRN antisauvagine-30 (ASV-30), a relatively selective CRF2 antagonist. These data suggest that CRF1 and CRF2 activation within the DRN affect 5-HT neurons in opponent fashion. Implications of these results for understanding the behavioral effects of CRF and other CRF-like ligands are discussed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0306-4522
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
509-19
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15541873-Amygdala,
pubmed-meshheading:15541873-Animals,
pubmed-meshheading:15541873-Cell Count,
pubmed-meshheading:15541873-Corticotropin-Releasing Hormone,
pubmed-meshheading:15541873-Diagnostic Imaging,
pubmed-meshheading:15541873-Dose-Response Relationship, Drug,
pubmed-meshheading:15541873-Drug Interactions,
pubmed-meshheading:15541873-Extracellular Space,
pubmed-meshheading:15541873-Immunohistochemistry,
pubmed-meshheading:15541873-Male,
pubmed-meshheading:15541873-Microdialysis,
pubmed-meshheading:15541873-Microinjections,
pubmed-meshheading:15541873-Peptide Fragments,
pubmed-meshheading:15541873-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:15541873-Raphe Nuclei,
pubmed-meshheading:15541873-Rats,
pubmed-meshheading:15541873-Serotonin,
pubmed-meshheading:15541873-Time Factors,
pubmed-meshheading:15541873-Urocortins
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pubmed:year |
2004
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pubmed:articleTitle |
Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala.
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pubmed:affiliation |
Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309-0345, USA. amat@psych.colorado.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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