Linked Life Data

15541818

Source:http://linkedlifedata.com/resource/pubmed/id/15541818

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-11-15
pubmed:abstractText
YKL-40, a growth factor for connective tissue cells, is secreted by cancer cells and macrophages. Elevated serum YKL-40 in patients with metastatic carcinoma has been associated with poor prognosis. We evaluated serum YKL-40 in 131 patients with small cell lung cancer (SCLC). Twenty-two percent of the patients with limited disease and 40% of the patients with extensive disease had elevated serum YKL-40. The median survival was 5.1 months for patients with elevated serum YKL-40 and 9.0 months for patients with normal serum YKL-40. Patients with elevated serum YKL-40 had increased hazard for death within the first 6 months after the start of chemotherapy compared to patients with normal serum YKL-40 (HR = 2.06, P = 0.009). Multivariate Cox analysis including routine prognostic variables showed that serum YKL-40 (P = 0.02) is independent of prognostic variables for survival within the first 6 months. Studies are needed to determine the function of YKL-40 in SCLC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0169-5002
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
333-40
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15541818-Adipokines, pubmed-meshheading:15541818-Adult, pubmed-meshheading:15541818-Aged, pubmed-meshheading:15541818-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:15541818-Autoantigens, pubmed-meshheading:15541818-Carcinoma, Small Cell, pubmed-meshheading:15541818-Female, pubmed-meshheading:15541818-Glycoproteins, pubmed-meshheading:15541818-Humans, pubmed-meshheading:15541818-Lectins, pubmed-meshheading:15541818-Life Expectancy, pubmed-meshheading:15541818-Lung Neoplasms, pubmed-meshheading:15541818-Male, pubmed-meshheading:15541818-Middle Aged, pubmed-meshheading:15541818-Neoplasm Staging, pubmed-meshheading:15541818-Prognosis, pubmed-meshheading:15541818-Prospective Studies, pubmed-meshheading:15541818-Survival Analysis, pubmed-meshheading:15541818-Treatment Outcome
pubmed:year
2004
pubmed:articleTitle
High serum YKL-40 level in patients with small cell lung cancer is related to early death.
pubmed:affiliation
Department of Medicine, Division of Rheumatology Q, Herlev Hospital, Herlev Ringvej 75, Herlev DK-2730, Denmark. julia.johansen@post3.tele.dk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study