rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5 Pt 1
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pubmed:dateCreated |
2004-11-15
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pubmed:abstractText |
Tadalafil, a phosphodiesterase type 5 inhibitor, is effective therapy for erectile dysfunction (ED). Men with ED have a high incidence of comorbid conditions including cardiovascular disease, diabetes mellitus and benign prostatic hyperplasia. Although phosphodiesterase type 5 inhibitors are safe when administered with most medications, sildenafil given with doxazosin and vardenafil given with terazosin evoke orthostatic hypotension in some patients. We examined the hemodynamic interactions of tadalafil with the alpha-blockers doxazosin and tamsulosin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3',5'-Cyclic-GMP Phosphodiesterases,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Carbolines,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide...,
http://linkedlifedata.com/resource/pubmed/chemical/Doxazosin,
http://linkedlifedata.com/resource/pubmed/chemical/PDE5A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Diester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/tadalafil,
http://linkedlifedata.com/resource/pubmed/chemical/tamsulosin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1935-40
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15540759-3',5'-Cyclic-GMP Phosphodiesterases,
pubmed-meshheading:15540759-Adrenergic alpha-Antagonists,
pubmed-meshheading:15540759-Aged,
pubmed-meshheading:15540759-Carbolines,
pubmed-meshheading:15540759-Cross-Over Studies,
pubmed-meshheading:15540759-Cyclic Nucleotide Phosphodiesterases, Type 5,
pubmed-meshheading:15540759-Double-Blind Method,
pubmed-meshheading:15540759-Doxazosin,
pubmed-meshheading:15540759-Drug Interactions,
pubmed-meshheading:15540759-Hemodynamics,
pubmed-meshheading:15540759-Humans,
pubmed-meshheading:15540759-Male,
pubmed-meshheading:15540759-Middle Aged,
pubmed-meshheading:15540759-Phosphoric Diester Hydrolases,
pubmed-meshheading:15540759-Sulfonamides
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pubmed:year |
2004
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pubmed:articleTitle |
Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men.
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pubmed:affiliation |
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90017, USA. rkloner@goodsam.org
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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