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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5 Pt 1
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pubmed:dateCreated |
2004-11-15
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pubmed:abstractText |
Prostate cancer is an androgen sensitive disease. Cytochrome P450 3A4 (CYP3A4) oxidatively deactivates testosterone by converting it to biologically less active metabolites. Previous studies suggest that a germline genetic variant in the 5' regulatory region of the gene may interfere with deactivation and increase the risk of clinically advanced prostate cancer. We investigated the impact of this polymorphism on the risk of recurrence after prostatectomy.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1848-52
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15540736-African Continental Ancestry Group,
pubmed-meshheading:15540736-Aged,
pubmed-meshheading:15540736-Cytochrome P-450 CYP3A,
pubmed-meshheading:15540736-Cytochrome P-450 Enzyme System,
pubmed-meshheading:15540736-Disease-Free Survival,
pubmed-meshheading:15540736-European Continental Ancestry Group,
pubmed-meshheading:15540736-Humans,
pubmed-meshheading:15540736-Male,
pubmed-meshheading:15540736-Middle Aged,
pubmed-meshheading:15540736-Prospective Studies,
pubmed-meshheading:15540736-Prostatectomy,
pubmed-meshheading:15540736-Prostatic Neoplasms
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pubmed:year |
2004
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pubmed:articleTitle |
CYP3A4 genetic variant and disease-free survival among white and black men after radical prostatectomy.
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pubmed:affiliation |
Barbara Ann Karmanos Cancer Institute, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. ipowell@med.wayne.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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