rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
9
|
pubmed:dateCreated |
2004-11-15
|
pubmed:abstractText |
Neuroligins are cell adhesion proteins that are thought to instruct the formation and alignment of synaptic specializations. The three known rodent neuroligin isoforms share homologous extracellular acetylcholinesterase-like domains that bridge the synaptic cleft and bind beta-neurexins. All neuroligins have identical intracellular C-terminal motifs that bind to PDZ domains of various target proteins. Neuroligin 1 is specifically localized to glutamatergic postsynaptic specializations. We show here that neuroligin 2 is exclusively localized to inhibitory synapses in rat brain and dissociated neurons. In immature neurons, neuroligin 2 is found at synapses and also at GABAA receptor aggregates that are not facing presynaptic termini, indicating that postsynaptic mechanisms lead to synaptic recruitment of neuroligin 2. Our findings identify neuroligin 2 as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0171-9335
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
83
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
449-56
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15540461-Animals,
pubmed-meshheading:15540461-Brain,
pubmed-meshheading:15540461-COS Cells,
pubmed-meshheading:15540461-Cell Adhesion Molecules,
pubmed-meshheading:15540461-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:15540461-Cell Line,
pubmed-meshheading:15540461-Cercopithecus aethiops,
pubmed-meshheading:15540461-Gene Expression Regulation, Developmental,
pubmed-meshheading:15540461-Humans,
pubmed-meshheading:15540461-Membrane Proteins,
pubmed-meshheading:15540461-Mice,
pubmed-meshheading:15540461-Nerve Tissue Proteins,
pubmed-meshheading:15540461-Neural Inhibition,
pubmed-meshheading:15540461-Neurons,
pubmed-meshheading:15540461-RNA, Messenger,
pubmed-meshheading:15540461-Rats,
pubmed-meshheading:15540461-Synapses
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pubmed:year |
2004
|
pubmed:articleTitle |
Neuroligin 2 is exclusively localized to inhibitory synapses.
|
pubmed:affiliation |
Max-Planck-Institute for Experimental Medicine, Department of Molecular Neurobiology, Göttingen, Germany.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|