Linked Life Data

15540226

Source:http://linkedlifedata.com/resource/pubmed/id/15540226

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-11-23
pubmed:abstractText
A series of antiviral active compounds consisting of an intercalating acridine-derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence. Thus, suitably mono-protected 1,omega-alkyldiamines gave, upon reaction with 9-chloro-2-trifluoromethoxyacridine, followed by deprotection and reaction with EDTA dianhydride, the target molecules. Incorporation of their Fe(II) complexes in the presence of ascorbate gave a reduction of the phage titer of MS2 phages by several logarithmic decades.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0365-6233
pubmed:author
pubmed:issnType
Print
pubmed:volume
337
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
571-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Synthesis of dimeric trifluoromethoxyacridine-derived pathogen-inactivating nucleic acid intercalators.
pubmed:affiliation
Institut für Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, D-06120 Halle (Saale), Germany. csuk@chemie.uni-halle.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't