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pubmed-article:15539333rdf:typepubmed:Citationlld:pubmed
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pubmed-article:15539333pubmed:issue9lld:pubmed
pubmed-article:15539333pubmed:dateCreated2004-11-12lld:pubmed
pubmed-article:15539333pubmed:abstractTextWe have previously shown that beta-carotene supplementation of the diets of healthy U.S. mothers increases serum and milk beta-carotene concentrations. Building on these results, we investigated the possibility that beta-carotene supplementation could enhance the vitamin A status of mothers and their nursing infants. Three 30-mg doses of beta-carotene were administered on 3 consecutive days to 44 lactating mothers who had vitamin-A-poor diets. Concentrations of maternal serum and milk carotenoids and retinol were evaluated at baseline and after 2 and 3 days of supplementation. Infant serum carotenoids and retinol were measured at baseline and 2 days following maternal supplementation. beta-Carotene supplementation markedly elevated maternal serum and milk beta-carotene concentrations (nine- and sevenfold, respectively) and resulted in smaller, transient increases of alpha-carotene, lycopene, and beta-cryptoxanthin concentrations in maternal serum. Maternal serum and milk retinol were unchanged in response to the treatment. In contrast, maternal beta-carotene supplementation significantly increased infant serum retinol (P </= 0.001) and beta-carotene concentrations remained unchanged. These results imply that breast milk beta-carotene can supply retinol for the nursing infant. Further research is needed to identify the site of bioconversion of milk-derived beta-carotene to retinol and to describe the factors that regulate this process.lld:pubmed
pubmed-article:15539333pubmed:languageenglld:pubmed
pubmed-article:15539333pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15539333pubmed:statusPubMed-not-MEDLINElld:pubmed
pubmed-article:15539333pubmed:monthSeplld:pubmed
pubmed-article:15539333pubmed:issn0955-2863lld:pubmed
pubmed-article:15539333pubmed:authorpubmed-author:CanfieldL MLMlld:pubmed
pubmed-article:15539333pubmed:authorpubmed-author:KaminskyR GRGlld:pubmed
pubmed-article:15539333pubmed:authorpubmed-author:TarenD LDLlld:pubmed
pubmed-article:15539333pubmed:authorpubmed-author:MahalZZlld:pubmed
pubmed-article:15539333pubmed:issnTypePrintlld:pubmed
pubmed-article:15539333pubmed:volume10lld:pubmed
pubmed-article:15539333pubmed:ownerNLMlld:pubmed
pubmed-article:15539333pubmed:authorsCompleteYlld:pubmed
pubmed-article:15539333pubmed:pagination532-8lld:pubmed
pubmed-article:15539333pubmed:year1999lld:pubmed
pubmed-article:15539333pubmed:articleTitleShort-term beta-carotene supplementation of lactating mothers consuming diets low in vitamin A.lld:pubmed
pubmed-article:15539333pubmed:affiliationThe University Department of Biochemistry, University of Arizona, Tucson, AZ 85721, USA.lld:pubmed
pubmed-article:15539333pubmed:publicationTypeJournal Articlelld:pubmed
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