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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0010124,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0033268,
umls-concept:C0214356,
umls-concept:C0442805,
umls-concept:C0521428,
umls-concept:C0574895,
umls-concept:C1151015,
umls-concept:C1280500,
umls-concept:C1514559,
umls-concept:C1948023
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pubmed:issue |
5
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pubmed:dateCreated |
2004-11-12
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pubmed:abstractText |
The antagonism of Agouti protein (AP) and Agouti-related protein on melanocortin receptors suggests an inhibitory role in the regulation of steroidogenesis. However, we have previously demonstrated that ectopic AP overexpression increased restraint-induced corticosterone release and adrenal reactivity to ACTH in mice. A high steroidogenic response to ACTH may be a consequence of a stimulatory AP action on the adenylate cyclase (AC) and/or intracellular steroidogenic enzymes. The aim of the present study was to estimate the effect of ectopic AP overexpression on the activity of AC and steroidogenic intracellular enzymes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenocorticotropic Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Agouti Signaling Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Agouti-Related Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Agrp protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Bucladesine,
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/nonagouti protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0804-4643
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
613-8
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pubmed:dateRevised |
2011-8-3
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pubmed:meshHeading |
pubmed-meshheading:15538940-Adenylate Cyclase,
pubmed-meshheading:15538940-Adrenal Glands,
pubmed-meshheading:15538940-Adrenocorticotropic Hormone,
pubmed-meshheading:15538940-Agouti Signaling Protein,
pubmed-meshheading:15538940-Agouti-Related Protein,
pubmed-meshheading:15538940-Animals,
pubmed-meshheading:15538940-Bucladesine,
pubmed-meshheading:15538940-Corticosterone,
pubmed-meshheading:15538940-Cyclic AMP,
pubmed-meshheading:15538940-Forskolin,
pubmed-meshheading:15538940-Genes, Dominant,
pubmed-meshheading:15538940-Genotype,
pubmed-meshheading:15538940-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:15538940-Male,
pubmed-meshheading:15538940-Mice,
pubmed-meshheading:15538940-Mice, Inbred C57BL,
pubmed-meshheading:15538940-Mutation,
pubmed-meshheading:15538940-Progesterone,
pubmed-meshheading:15538940-Tissue Distribution
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pubmed:year |
2004
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pubmed:articleTitle |
Ectopic Agouti protein overexpression increases stimulated corticosterone production without effect on adenylate cyclase activity in mouse adrenal cells.
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pubmed:affiliation |
Institute of Cytology and Genetics of the Russian Academy of Sciences, Pr. Lavrentjeva 10, Novosibirsk 630090, Russia. antonyna2000@yandex.ru
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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