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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-3-30
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pubmed:abstractText |
Hypoxia-inducible factor-1alpha (HIF-1alpha) regulates cellular responses to hypoxia and is rapidly degraded under normoxia through von Hippel-Lindau (VHL) mediated ubiquitination. Although HIF-1alpha stabilization appears to be the molecular basis for VHL-associated cancers, stabilizing mutations in HIF-1alpha have not been reported.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2004 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
215-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15538748-Biopsy,
pubmed-meshheading:15538748-Bone Marrow,
pubmed-meshheading:15538748-Cell Line,
pubmed-meshheading:15538748-DNA, Neoplasm,
pubmed-meshheading:15538748-Genetic Predisposition to Disease,
pubmed-meshheading:15538748-Humans,
pubmed-meshheading:15538748-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:15538748-Luciferases,
pubmed-meshheading:15538748-Male,
pubmed-meshheading:15538748-Mixed Function Oxygenases,
pubmed-meshheading:15538748-Mutagenesis, Site-Directed,
pubmed-meshheading:15538748-Mutation,
pubmed-meshheading:15538748-Oxygen,
pubmed-meshheading:15538748-Polymerase Chain Reaction,
pubmed-meshheading:15538748-Prostatic Neoplasms,
pubmed-meshheading:15538748-Recombinant Fusion Proteins,
pubmed-meshheading:15538748-Sequence Analysis, DNA,
pubmed-meshheading:15538748-Transcription, Genetic,
pubmed-meshheading:15538748-Transcription Factors,
pubmed-meshheading:15538748-Transfection
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pubmed:year |
2005
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pubmed:articleTitle |
Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation.
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pubmed:affiliation |
Cancer Biology Program, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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