|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
2004-11-11
|
|
pubmed:abstractText |
The neurotoxicity of the AMPA/kainate receptor agonist kainate was investigated in motor and cortical neurones from mice over-expressing the wild-type and G93A mutant form of Cu/Zn superoxide dismutase (SOD1) human gene, a mouse model of familial amyotrophic lateral sclerosis. G93A mutant motor neurones were more vulnerable and wild-type SOD1 motor neurones were more resistant to kainate toxicity than were controls. Voltage-gated Na channels blockage prevented G93A mutant SOD1 motor neurone death. Cortical cultures exhibited fewer differences in their vulnerability to kainate toxicity. These results demonstrate that SOD1 over-expression selectively affects the sensitivity to kainate excitotoxicity of motor neurones but not neocortical neurones, and that wild-type SOD1 expression increases the resistance to excitotoxicity of motor neurones.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Asparagine,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Cobalt,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Nifedipine,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphopyruvate Hydratase,
http://linkedlifedata.com/resource/pubmed/chemical/SOD1 G93A protein,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0959-4965
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2477-80
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15538178-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:15538178-Analysis of Variance,
pubmed-meshheading:15538178-Animals,
pubmed-meshheading:15538178-Asparagine,
pubmed-meshheading:15538178-Calcium Channel Blockers,
pubmed-meshheading:15538178-Cell Count,
pubmed-meshheading:15538178-Cell Survival,
pubmed-meshheading:15538178-Cells, Cultured,
pubmed-meshheading:15538178-Cerebral Cortex,
pubmed-meshheading:15538178-Cobalt,
pubmed-meshheading:15538178-Disease Models, Animal,
pubmed-meshheading:15538178-Dose-Response Relationship, Drug,
pubmed-meshheading:15538178-Drug Interactions,
pubmed-meshheading:15538178-Embryo, Mammalian,
pubmed-meshheading:15538178-Female,
pubmed-meshheading:15538178-Glial Fibrillary Acidic Protein,
pubmed-meshheading:15538178-Glutamic Acid,
pubmed-meshheading:15538178-Immunohistochemistry,
pubmed-meshheading:15538178-Kainic Acid,
pubmed-meshheading:15538178-Male,
pubmed-meshheading:15538178-Mice,
pubmed-meshheading:15538178-Mice, Transgenic,
pubmed-meshheading:15538178-Motor Neurons,
pubmed-meshheading:15538178-Neurotoxins,
pubmed-meshheading:15538178-Nifedipine,
pubmed-meshheading:15538178-Phosphopyruvate Hydratase,
pubmed-meshheading:15538178-Sodium Channel Blockers,
pubmed-meshheading:15538178-Spinal Cord,
pubmed-meshheading:15538178-Superoxide Dismutase,
pubmed-meshheading:15538178-Tetrodotoxin,
pubmed-meshheading:15538178-Time Factors
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Altered vulnerability to kainate excitotoxicity of transgenic-Cu/Zn SOD1 neurones.
|
|
pubmed:affiliation |
IRCCS Fondazione Santa Lucia Via Ardeatina 306 00179 Rome, Italy.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
