|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2004-11-11
|
|
pubmed:abstractText |
To define and minimize the N-terminal PTH pharmacophore, the effects of introducing different conformationally constraining di-alkyl amino acids at positions 1 and 3 of PTH(1-14) analogs were studied. Improvements in PTH receptor-binding affinity and signaling potency were found, although some substitutions resulted in partial agonism.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0884-0431
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2078-86
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15537452-Amino Acids,
pubmed-meshheading:15537452-Animals,
pubmed-meshheading:15537452-COS Cells,
pubmed-meshheading:15537452-Cell Line,
pubmed-meshheading:15537452-Circular Dichroism,
pubmed-meshheading:15537452-Cyclic AMP,
pubmed-meshheading:15537452-Dose-Response Relationship, Drug,
pubmed-meshheading:15537452-Inhibitory Concentration 50,
pubmed-meshheading:15537452-Inositol Phosphates,
pubmed-meshheading:15537452-Models, Chemical,
pubmed-meshheading:15537452-Parathyroid Hormone,
pubmed-meshheading:15537452-Peptide Fragments,
pubmed-meshheading:15537452-Peptides,
pubmed-meshheading:15537452-Protein Binding,
pubmed-meshheading:15537452-Protein Conformation,
pubmed-meshheading:15537452-Protein Structure, Secondary,
pubmed-meshheading:15537452-Protein Structure, Tertiary,
pubmed-meshheading:15537452-Signal Transduction,
pubmed-meshheading:15537452-Structure-Activity Relationship,
pubmed-meshheading:15537452-Swine,
pubmed-meshheading:15537452-Type C Phospholipases
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3.
|
|
pubmed:affiliation |
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
