|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
21
|
|
pubmed:dateCreated |
2004-11-9
|
|
pubmed:abstractText |
To optimize treatment strategies for postmenopausal breast cancer patients, we investigated the efficacy of the steroidal aromatase inhibitor exemestane alone or in combination with the antiestrogen tamoxifen in a xenograft model of postmenopausal breast cancer. We also determined the effects of these agents in sequential second-line therapy and the effect of the nonsteroidal aromatase inhibitor letrozole on tumors that progressed on the above treatments. Experimental: Aromatase-transfected human estrogen receptor-positive breast cancer cells (MCF-7Ca) were grown as tumors in ovariectomized athymic mice. Animals received subcutaneous injection with vehicle, tamoxifen, exemestane, tamoxifen plus exemestane, and letrozole. Tumor volumes were measured weekly.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
7375-81
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:15534114-Androstadienes,
pubmed-meshheading:15534114-Animals,
pubmed-meshheading:15534114-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15534114-Breast Neoplasms,
pubmed-meshheading:15534114-Cell Line, Tumor,
pubmed-meshheading:15534114-Disease Progression,
pubmed-meshheading:15534114-Dose-Response Relationship, Drug,
pubmed-meshheading:15534114-Female,
pubmed-meshheading:15534114-Humans,
pubmed-meshheading:15534114-Mammary Neoplasms, Animal,
pubmed-meshheading:15534114-Mice,
pubmed-meshheading:15534114-Mice, Inbred BALB C,
pubmed-meshheading:15534114-Mice, Nude,
pubmed-meshheading:15534114-Neoplasm Transplantation,
pubmed-meshheading:15534114-Neoplasms, Hormone-Dependent,
pubmed-meshheading:15534114-Nitriles,
pubmed-meshheading:15534114-Postmenopause,
pubmed-meshheading:15534114-Random Allocation,
pubmed-meshheading:15534114-Tamoxifen,
pubmed-meshheading:15534114-Time Factors,
pubmed-meshheading:15534114-Triazoles
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Effects of exemestane and tamoxifen in a postmenopausal breast cancer model.
|
|
pubmed:affiliation |
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
