Linked Life Data

15533769

Source:http://linkedlifedata.com/resource/pubmed/id/15533769

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-11-9
pubmed:abstractText
During development, the definitive endoderm differentiates into several gastrointestinal epithelial lineages, including enteroendocrine cells. The enteroendocrine lineage consists of at least 15 different cell types that are categorized based on their morphology, location and peptide hormone expression. The mechanisms regulating enteroendocrine cell differentiation are likely to be critical not only in embryonic development, but also during the constant renewal of gut epithelia in the adult. The identification of transcription factors and regulatory DNA elements required for cell type-specific gene expression in various endocrine cell types has broadened our understanding of the regulatory networks controlling the spatial and temporal activation of enteroendocrine differentiation programs. This chapter will review recent studies of transcription factors during enteroendocrine cell differentiation, with a focus on the central role for the Notch signaling pathway in enteroendocrine cell fate decisions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1521-690X
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
453-62
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Clinical endocrinology and metabolism. Development of gut endocrine cells.
pubmed:affiliation
Department of Genetics and Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review