Linked Life Data

15531408

Source:http://linkedlifedata.com/resource/pubmed/id/15531408

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-11-8
pubmed:abstractText
Schizophrenia, as a single disease entity, has been the major paradigm during the past 100 years. Classification has increasingly emphasized diagnostically discriminating psychotic symptoms. This has made reality distortion and thought disorder the defining qualities of the disorder. One result is 50 years of developing dopamine antagonist antipsychotic drugs while neglecting novel therapeutic pathways related to nonpsychotic pathology. The domains of psychopathology provides an alternative paradigm. In this paradigm, the relative independence of reality distortion, disorganization, negative pathology, and impairments in cognition is stressed. Application of this paradigm has revealed that impaired cognition and negative symptoms are robustly associated with poor functional outcomes. Antipsychotic drugs fail to address these pathologies. These unmet treatment needs are clinical targets for drug discovery involving novel therapeutic pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0920-9964
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-73
pubmed:dateRevised
2010-9-2
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Clinical constructs and therapeutic discovery.
pubmed:affiliation
University of Maryland Baltimore, Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA. wcarpent@mprc.umaryland.edu
pubmed:publicationType
Journal Article, Review