rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
|
pubmed:dateCreated |
2004-11-10
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pubmed:abstractText |
Defensins are broad-spectrum antimicrobial peptides that are components of innate immunity. To date, only epithelial surfaces and blood cells have been shown to produce these cationic peptides in bactericidal concentrations when challenged with microorganisms or inflammatory cytokines. Infections caused by gram-negative pathogens occur only infrequently in association with joint surgery. The present study was undertaken to investigate whether this may be explained by intraarticular production of gram-negative-specialized antimicrobial peptides.
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pubmed:grant |
|
pubmed:commentsCorrections |
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pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0004-3591
|
pubmed:author |
pubmed-author:GoldringMary BMB,
pubmed-author:HarderJürgenJ,
pubmed-author:MentleinRolfR,
pubmed-author:Meyer-HoffertUlfU,
pubmed-author:PaulsenFriedrich PFP,
pubmed-author:PetersenWolf JWJ,
pubmed-author:ProkschEhrhardtE,
pubmed-author:PufeThomasT,
pubmed-author:SchröderJens-MichaelJM,
pubmed-author:TillmannBernhard NBN,
pubmed-author:VarogaDeikeD
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pubmed:issnType |
Print
|
pubmed:volume |
50
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
3526-34
|
pubmed:dateRevised |
2010-9-17
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pubmed:meshHeading |
pubmed-meshheading:15529375-Adult,
pubmed-meshheading:15529375-Animals,
pubmed-meshheading:15529375-Anti-Infective Agents,
pubmed-meshheading:15529375-Arthritis, Infectious,
pubmed-meshheading:15529375-Cartilage, Articular,
pubmed-meshheading:15529375-Cells, Cultured,
pubmed-meshheading:15529375-Chondrocytes,
pubmed-meshheading:15529375-Humans,
pubmed-meshheading:15529375-Lipopolysaccharides,
pubmed-meshheading:15529375-Mice,
pubmed-meshheading:15529375-Osmolar Concentration,
pubmed-meshheading:15529375-Pseudomonas Infections,
pubmed-meshheading:15529375-Staphylococcal Infections,
pubmed-meshheading:15529375-Tumor Necrosis Factor-alpha,
pubmed-meshheading:15529375-beta-Defensins
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pubmed:year |
2004
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pubmed:articleTitle |
Production of endogenous antibiotics in articular cartilage.
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pubmed:affiliation |
Schleswig-Holstein University and University Hospital, 24098 Kiel, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|