Linked Life Data

15528122

Source:http://linkedlifedata.com/resource/pubmed/id/15528122

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-11-5
pubmed:abstractText
With the advent of magnetic resonance imaging (MRI), it is possible to obtain high-resolution anatomical images of the monkey brain. Accuracy, however, is lost in the laboratory or surgical setting when the localization of brain structures depends on nonstereotaxic tracking methods. Here we present an image-guided stereotaxic system that is able to localize and access anatomical brain structures using the monkey's MRI. This system, which is also known as frameless stereotaxy, is capable of computing the relation of the physical "real space" of the monkey's head to the corresponding image space, while a position sensor enables the tracking of the animal's head and the localization of brain areas and favorable paths to targets within the brain using real time display software. Surgical procedures make use of an adjustable upright chair and a surgical headclamp instead of the traditional restrictive head holder with ear bars. This novel system allows for the flexible positioning of the animal and the ability to reach areas of the brain that were difficult to access in the past. The headclamp also serves as a tool holder, which in the present application guided a cannula of retrograde tracer to the desired location in the frontal lobe. Histological examination of the brain showed that the injection reached the target site, and tests using an MRI compatible phantom demonstrated that the precision of the system in bringing an injection to target is less than 1.2 mm. This system can be used to inject accurately tracers for anatomical tract-tracing, to make precise lesions, and to position electrodes for electrophysiological studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1053-8119
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1226-34
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Frameless stereotaxy in the nonhuman primate.
pubmed:affiliation
Montreal Neurological Institute, McGill University, Montreal, 3801 University Street, Montreal, Quebec, Canada H3A 2B4. Stephen@bic.mni.mcgill.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't