rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
2004-11-5
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pubmed:abstractText |
Multiple sclerosis (MS) is believed to be an autoimmune disease of the human central nervous system mediated by autoreactive T cells. Interferon-beta1b (IFN-beta1b) has been shown to be effective in reducing disease activity defined by clinical and magnetic resonance imaging (MRI) criteria in relapsing-remitting MS (RRMS). Yet, the exact mechanisms by which these benefits are achieved remain unknown. CD45RA is a marker for naive T lymphocytes and intercellular adhesion molecule-3 (ICAM-3) is expressed on resting lymphocytes.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/ICAM3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/interferon beta-1b
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0001-6314
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pubmed:author |
pubmed-author:BauerRR,
pubmed-author:BlaesFF,
pubmed-author:BregenzerTT,
pubmed-author:ChatzimanolisNN,
pubmed-author:EngelhardtBB,
pubmed-author:KappBB,
pubmed-author:KrausJJ,
pubmed-author:KuehneB SBS,
pubmed-author:MEHTAV PVP,
pubmed-author:OschmannPP,
pubmed-author:StollWW,
pubmed-author:TofighiJJ,
pubmed-author:TraupeHH,
pubmed-author:VoigtKK
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pubmed:issnType |
Print
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pubmed:volume |
110
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
377-85
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15527450-Adjuvants, Immunologic,
pubmed-meshheading:15527450-Adult,
pubmed-meshheading:15527450-Antigens, CD,
pubmed-meshheading:15527450-Antigens, CD45,
pubmed-meshheading:15527450-Biological Markers,
pubmed-meshheading:15527450-Cell Adhesion Molecules,
pubmed-meshheading:15527450-Female,
pubmed-meshheading:15527450-Humans,
pubmed-meshheading:15527450-Injections, Subcutaneous,
pubmed-meshheading:15527450-Interferon-beta,
pubmed-meshheading:15527450-Lymphocyte Subsets,
pubmed-meshheading:15527450-Magnetic Resonance Imaging,
pubmed-meshheading:15527450-Male,
pubmed-meshheading:15527450-Middle Aged,
pubmed-meshheading:15527450-Multiple Sclerosis,
pubmed-meshheading:15527450-Recombinant Proteins,
pubmed-meshheading:15527450-Recurrence
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pubmed:year |
2004
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pubmed:articleTitle |
CD45RA+ ICAM-3+ lymphocytes in interferon-beta1b-treated and -untreated patients with relapsing-remitting multiple sclerosis.
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pubmed:affiliation |
Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, Justus-Liebig University of Giessen, Giessen, Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|