| pubmed-article:15525444 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15525444 | lifeskim:mentions | umls-concept:C0018242 | lld:lifeskim |
| pubmed-article:15525444 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:15525444 | lifeskim:mentions | umls-concept:C1269765 | lld:lifeskim |
| pubmed-article:15525444 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15525444 | pubmed:dateCreated | 2004-11-4 | lld:pubmed |
| pubmed-article:15525444 | pubmed:abstractText | Supercritical assisted atomization (SAA) was used to micronize griseofulvin (GF), selected as a model compound, to verify the performance of this innovative process. SAA is based on the solubilization of supercritical carbon dioxide in a liquid solution containing the drug. The ternary mixture is then sprayed through a nozzle and microparticles are formed as a consequence of the enhanced atomization. Precipitation temperature and drug concentration in the liquid solution were studied to evaluate their influence on morphology and size of precipitated particles. A good particle size control was obtained and GF spherical particles with mean diameters ranging from 0.5 to 2.5 microm were produced with a narrow particle size distribution. Processed GF was characterized by high-performance liquid chromatography-UV/vis, headspace-gas chromatography-flame ionization detection, differential scanning calorimetry, BET and X-ray analyses. No drug degradation was observed and a solvent residue (acetone) less than 800 ppm was measured. GF microparticles showed good stability and surface areas ranging from about 4 to 6 m(2) g(-1); moreover, the micronized drug retained the crystalline habit. GF capsules were formulated with starch and used to compare the dissolution rate of SAA-processed and conventional jet-milled drug. A faster dissolution and a better reproducibility of the dissolution profile were observed for SAA-processed GF. | lld:pubmed |
| pubmed-article:15525444 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15525444 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15525444 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15525444 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15525444 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15525444 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15525444 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15525444 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15525444 | pubmed:issn | 0022-3573 | lld:pubmed |
| pubmed-article:15525444 | pubmed:author | pubmed-author:SpadaAA | lld:pubmed |
| pubmed-article:15525444 | pubmed:author | pubmed-author:Della PortaGG | lld:pubmed |
| pubmed-article:15525444 | pubmed:author | pubmed-author:AntonacciAA | lld:pubmed |
| pubmed-article:15525444 | pubmed:author | pubmed-author:ReverchonEE | lld:pubmed |
| pubmed-article:15525444 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15525444 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:15525444 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15525444 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15525444 | pubmed:pagination | 1379-87 | lld:pubmed |
| pubmed-article:15525444 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15525444 | pubmed:meshHeading | pubmed-meshheading:15525444... | lld:pubmed |
| pubmed-article:15525444 | pubmed:meshHeading | pubmed-meshheading:15525444... | lld:pubmed |
| pubmed-article:15525444 | pubmed:meshHeading | pubmed-meshheading:15525444... | lld:pubmed |
| pubmed-article:15525444 | pubmed:meshHeading | pubmed-meshheading:15525444... | lld:pubmed |
| pubmed-article:15525444 | pubmed:meshHeading | pubmed-meshheading:15525444... | lld:pubmed |
| pubmed-article:15525444 | pubmed:meshHeading | pubmed-meshheading:15525444... | lld:pubmed |
| pubmed-article:15525444 | pubmed:meshHeading | pubmed-meshheading:15525444... | lld:pubmed |
| pubmed-article:15525444 | pubmed:meshHeading | pubmed-meshheading:15525444... | lld:pubmed |
| pubmed-article:15525444 | pubmed:meshHeading | pubmed-meshheading:15525444... | lld:pubmed |
| pubmed-article:15525444 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15525444 | pubmed:articleTitle | Griseofulvin micronization and dissolution rate improvement by supercritical assisted atomization. | lld:pubmed |
| pubmed-article:15525444 | pubmed:affiliation | Dipartimento di Ingegneria Chimica e Alimentare, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy. ereverchon@unisat.it | lld:pubmed |
| pubmed-article:15525444 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15525444 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15525444 | lld:pubmed |
