Source:http://linkedlifedata.com/resource/pubmed/id/15525351
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2004-11-4
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| pubmed:abstractText |
To investigate the molecular background of vestibular compensation, a model of lesion-induced plasticity, we used a microarray analysis to examine genes that show asymmetrical expression between the bilateral vestibular nucleus complexes (VNCs) 6 h following unilateral vestibular deafferentation (UVD). Asymmetrical gene expression was then validated by a real-time quantitative PCR. Among the 88 genes for which the ipsilateral (ipsi) : contralateral (contra) was > 1.35, the number of known genes was 33 (38%), and the number of expressed sequence tag (EST) sequences was 55 (62%). Among the 130 genes for which the contra : ipsi was > 1.35, the number of known genes was 55 (42%), and the number of EST sequences was 75 (58%). Changes in some of the genes were consistent with previous studies; however, we found several new genes which could be functionally related to the molecular basis of the electrophysiological asymmetry between the VNCs following UVD. Ipsi > contra genes included the GABA(A) receptor rho subunit, regulatory proteins of G protein signaling, calcium signaling related molecules such as the voltage-dependent calcium channel alpha2/delta subunit 1, calcineurin subunit Abeta and Ca(2+) pump. Contra > ipsi genes included the neuronal high affinity glutamate transporter, 5-hydroxytryptamine receptor 1D, mitogen-activated protein kinase 12 and ubiquitin carboxy-terminal hydrolase L1.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcineurin,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RGS Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Strn protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/regulator of g-protein signaling 9
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0022-3042
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
91
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
975-82
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15525351-Animals,
pubmed-meshheading:15525351-Calcineurin,
pubmed-meshheading:15525351-Calmodulin-Binding Proteins,
pubmed-meshheading:15525351-Denervation,
pubmed-meshheading:15525351-Ear, Inner,
pubmed-meshheading:15525351-Expressed Sequence Tags,
pubmed-meshheading:15525351-Functional Laterality,
pubmed-meshheading:15525351-Gene Expression Profiling,
pubmed-meshheading:15525351-Male,
pubmed-meshheading:15525351-Membrane Proteins,
pubmed-meshheading:15525351-Nerve Tissue Proteins,
pubmed-meshheading:15525351-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:15525351-RGS Proteins,
pubmed-meshheading:15525351-Rats,
pubmed-meshheading:15525351-Rats, Wistar,
pubmed-meshheading:15525351-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15525351-Vestibular Nuclei,
pubmed-meshheading:15525351-Vestibule, Labyrinth
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| pubmed:year |
2004
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| pubmed:articleTitle |
Microarray analysis of gene expression in the rat vestibular nucleus complex following unilateral vestibular deafferentation.
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| pubmed:affiliation |
Department of Otolaryngology, Osaka University Medical School, Osaka, Japan. ahorii@ent.med.osaka-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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