Linked Life Data

15523909

Source:http://linkedlifedata.com/resource/pubmed/id/15523909

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2004-11-4
pubmed:abstractText
BACKGROUND: Genetic instability is a characteristic feature of familial and sporadic breast carcinomas. It is not clear whether defects in the mismatch repair system accompany this instability. The purpose of this study was to explore the expression of two of the proteins encoded by the DNA mismatch repair genes, namely MLH1 and MSH2, in sporadic in situ and invasive breast carcinomas of various types and grades occurring in Greek patients. MATERIALS AND METHODS: MLH1 and MSH2 expression was monitored immunohistochemically in 60 breast carcinomas (20 in situ and 40 invasive). RESULTS-CONCLUSION: Although we did not detect loss of MLH1 or MSH2 expression, we do believe that our data will contribute to a better understanding of the role of the mismatch repair (MMR) system in breast cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0258-851X
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
661-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Expression of mismatch repair proteins in invasive and in situ carcinoma of the breast.
pubmed:affiliation
Department of Pathology, University of Ioannina, Medical School, 451 10, Ioannina, Greece.
pubmed:publicationType
Journal Article