Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-11-19
pubmed:abstractText
Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. We demonstrate a role for Bmal1 and Clock in the regulation of glucose homeostasis. Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides. Gluconeogenesis is abolished by deletion of Bmal1 and is depressed in Clock mutants, but the counterregulatory response of corticosterone and glucagon to insulin-induced hypoglycaemia is retained. Furthermore, a high-fat diet modulates carbohydrate metabolism by amplifying circadian variation in glucose tolerance and insulin sensitivity, and mutation of Clock restores the chow-fed phenotype. Bmal1 and Clock, genes that function in the core molecular clock, exert profound control over recovery from insulin-induced hypoglycaemia. Furthermore, asynchronous dietary cues may modify glucose homeostasis via their interactions with peripheral molecular clocks.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-10196587, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-10433238, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-10891488, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11114885, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11161204, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11163178, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11375322, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11439184, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11479627, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11533719, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11551845, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11739286, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11742409, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11773865, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11937022, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-11967526, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12015981, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12068289, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12198538, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12213820, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12438446, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12546272, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12787789, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12865428, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12894240, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12934012, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12958601, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-12970157, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-1425110, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-14709204, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-14715703, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-15296754, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-2237405, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-3237790, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-3301441, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-3394934, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-427554, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-443421, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-4685092, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-5372892, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-5572981, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-5885941, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-6336816, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-6759239, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-7190752, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-8171325, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-837222, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-8447379, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-9160755, http://linkedlifedata.com/resource/pubmed/commentcorrection/15523558-9356024
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1545-7885
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e377
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
More...