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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-11-3
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pubmed:abstractText |
It has been recently shown that the expression of various types of neurotransmitter receptors is not restricted to neurons but also observed in a majority of glial cells. However, their function in glial cells is not known well in both physiological and pathological conditions. Here, we investigated the role of glutamate receptor on c-fos gene expression in primary cultured and BV-2 microglia. Our results demonstrated that both c-fos mRNA and protein were dramatically induced following treatment with various glutamate receptor agonists (500muM); N-methyl-d-aspartic acid, kainic acid, (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, and (RS)-3,5-dihydroxyphenylglycine. The responses were significantly suppressed by specific antagonists and also by calcium chelating agents EGTA and BAPTA-AM. Our results suggest that glutamate receptor activation regulates c-fos gene expression by modifying intracellular calcium levels in microglia. These findings might provide an insight in to understanding the function of microglial glutamate receptors in neuron-to-glial interaction under the excitotoxic conditions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chelating Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
325
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
320-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15522236-Animals,
pubmed-meshheading:15522236-Animals, Newborn,
pubmed-meshheading:15522236-Calcium,
pubmed-meshheading:15522236-Cells, Cultured,
pubmed-meshheading:15522236-Chelating Agents,
pubmed-meshheading:15522236-Excitatory Amino Acid Agonists,
pubmed-meshheading:15522236-Excitatory Amino Acid Antagonists,
pubmed-meshheading:15522236-Gene Expression Regulation,
pubmed-meshheading:15522236-Glutamic Acid,
pubmed-meshheading:15522236-Mice,
pubmed-meshheading:15522236-Microglia,
pubmed-meshheading:15522236-Nitric Oxide Synthase,
pubmed-meshheading:15522236-Nitric Oxide Synthase Type II,
pubmed-meshheading:15522236-Protein Isoforms,
pubmed-meshheading:15522236-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:15522236-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:15522236-Rats,
pubmed-meshheading:15522236-Rats, Sprague-Dawley,
pubmed-meshheading:15522236-Receptors, Glutamate,
pubmed-meshheading:15522236-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Glutamate receptor-mediated regulation of c-fos expression in cultured microglia.
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pubmed:affiliation |
Division of Brain Diseases, Department of Biomedical Sciences, National Institute of Health, 5 Nokbun-Dong, Eunpyung-Ku, Seoul 122-701, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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