Linked Life Data

1552194

Source:http://linkedlifedata.com/resource/pubmed/id/1552194

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-4-24
pubmed:abstractText
Pasteurella haemolytica, the cause of fibrinous pleuropneumonia in cattle, produces extensive microvascular endothelial cell damage. This study investigated endothelial cell-leukocyte interactions by using a Millicell coculture assay system that modeled the bovine pulmonary alveolar defense system and showed that P. haemolytica-mediated endothelial cell damage was enhanced by the presence of alveolar macrophages, presumably due to soluble alveolar macrophage products. The alveolar macrophage-enhanced endothelial cell damage occurred regardless of the presence of anti-P. haemolytica immune serum; however, neutrophils and immune serum effectively prevented endothelial cell damage. These results suggest that alveolar macrophages are ineffective in controlling P. haemolytica growth and actually promote endothelial cell damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
165
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
651-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Alveolar macrophage and neutrophil interactions in Pasteurella haemolytica-induced endothelial cell injury.
pubmed:affiliation
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37996-4500.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't