rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2004-11-2
|
pubmed:abstractText |
The extent and severity of mucosal injury in inflammatory bowel diseases are determined by the disequilibrium between 2 opposing processes: reparative and cytoprotective mechanisms vs. inflammation-induced injury. Probiotics may provide clinical benefit by ameliorating colitis; however, their mechanisms of action remain largely unknown. Our objective was to investigate microbial-epithelial interactions that could explain the beneficial therapeutic effects of probiotics.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Proteinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin,
http://linkedlifedata.com/resource/pubmed/chemical/lactacystin
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0016-5085
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
127
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1474-87
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:15521016-Acetylcysteine,
pubmed-meshheading:15521016-Animals,
pubmed-meshheading:15521016-Cell Survival,
pubmed-meshheading:15521016-Cells, Cultured,
pubmed-meshheading:15521016-Chemokine CCL2,
pubmed-meshheading:15521016-Colon,
pubmed-meshheading:15521016-Culture Media, Conditioned,
pubmed-meshheading:15521016-Cysteine Proteinase Inhibitors,
pubmed-meshheading:15521016-Intestinal Mucosa,
pubmed-meshheading:15521016-Mice,
pubmed-meshheading:15521016-NF-kappa B,
pubmed-meshheading:15521016-Probiotics,
pubmed-meshheading:15521016-Proteasome Endopeptidase Complex,
pubmed-meshheading:15521016-Ubiquitin
|
pubmed:year |
2004
|
pubmed:articleTitle |
Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition.
|
pubmed:affiliation |
Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|