Linked Life Data

15520821

Source:http://linkedlifedata.com/resource/pubmed/id/15520821

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-11-24
pubmed:abstractText
Children with Down syndrome (DS) are highly susceptible to acute leukaemia. Given the potential role of infections in the aetiology of leukaemia in children without DS, we investigated whether there was an association between early-life infections and acute leukaemia in children with DS. Maternal infections during pregnancy were also examined. We enrolled 158 incident cases of acute leukaemia in children with DS (97 acute lymphoblastic leukaemia (ALL) and 61 acute myeloid leukaemia (AML)) diagnosed at Children's Oncology Group institutions between 1997 and 2002. DS controls (N=173) were selected from the cases' primary care clinics and frequency matched on age at leukaemia diagnosis. Data were collected on demographics, child's medical history, mother's medical history, and other factors by maternal interview. Analyses were conducted using unconditional logistic regression adjusted for potential confounders. A significant negative association was observed between acute leukaemia and any infection in the first 2 years of life (adjusted odds ratio (OR)=0.55, 95% confidence interval (CI) (0.33-0.92); OR=0.53, 95% CI (0.29-0.97); and OR=0.59, 95% CI (0.28-1.25) for acute leukaemia combined, ALL, and AML respectively). The association between acute leukaemia and maternal infections during pregnancy was in the same direction but not significant. This study offers support for the hypothesis that early-life infections may play a protective role in the aetiology of acute leukaemia in children with DS.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-10408870, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-10424755, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-10468308, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-10638995, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-11276984, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-11305722, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-11353361, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-11953850, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-11984799, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-11986774, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-12599243, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-12791663, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-12970794, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-1389451, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-14710221, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-1532221, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-2955886, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-2958611, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-3278171, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-3463201, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-3859718, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-4256452, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-6218002, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-6235337, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-6704929, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-7689298, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-7713179, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-7753142, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-8445941, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-8630931, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-9024390, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-9558367, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-9917758, http://linkedlifedata.com/resource/pubmed/commentcorrection/15520821-9930130
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1866-72
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's Oncology Group.
pubmed:affiliation
Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Multicenter Study