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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-11-2
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pubmed:abstractText |
Pirfenidone has antiinflammatory effects in animals with endotoxemia. We reported that pirfenidone inhibits the enhancement of inflammatory cytokines and inducible nitric oxide synthase (iNOS) in liver of endotoxin-treated rats, leading to the prevention of hepatic injury. However, the mechanisms involved in suppression of these gene inductions are obscure. Studies were performed to investigate whether pirfenidone directly influences iNOS induction in hepatocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Akt1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridones,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/pirfenidone
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
730-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15519644-Animals,
pubmed-meshheading:15519644-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:15519644-Cells, Cultured,
pubmed-meshheading:15519644-Enzyme Induction,
pubmed-meshheading:15519644-Hepatocytes,
pubmed-meshheading:15519644-Interleukin-1,
pubmed-meshheading:15519644-Male,
pubmed-meshheading:15519644-NF-kappa B,
pubmed-meshheading:15519644-Nitric Oxide Synthase,
pubmed-meshheading:15519644-Nitric Oxide Synthase Type II,
pubmed-meshheading:15519644-Promoter Regions, Genetic,
pubmed-meshheading:15519644-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15519644-Proto-Oncogene Proteins,
pubmed-meshheading:15519644-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:15519644-Pyridones,
pubmed-meshheading:15519644-Rats,
pubmed-meshheading:15519644-Rats, Wistar,
pubmed-meshheading:15519644-Receptors, Interleukin-1,
pubmed-meshheading:15519644-Up-Regulation
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pubmed:year |
2004
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pubmed:articleTitle |
Pirfenidone inhibits the induction of iNOS stimulated by interleukin-1beta at a step of NF-kappaB DNA binding in hepatocytes.
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pubmed:affiliation |
The First Department of Surgery, Kansai Medical University, 10-15 Fumizonocho, Moriguchi, Osaka 570-8506, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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