Linked Life Data

15519510

Source:http://linkedlifedata.com/resource/pubmed/id/15519510

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2004-11-2
pubmed:abstractText
Adjuvant treatment strategies in uveal melanoma require determination of prognostic factors. Patients, who received primary therapy in 1994 and 1995 at our institution, were analysed. Of 271 patients 85% and 71% were available for follow up of 4 and 5 years. Forty three patients (15.9%) developed metastases. Kaplan-Meier analysis revealed a 5-year progression free survival (PFS) of 79% for the whole patient cohort. Extraocular tumor growth (EOG), ciliary body involvement or a largest tumor diameter (LTD) >14 mm were associated with a significantly lower 5-year PFS of 28%, 61.4% or 67.6%. In multivariate analysis time to progression was significantly associated with ciliary body involvement and LTD, and survival was associated with ciliary body involvement. Ciliary body involvement profoundly increased the risk for metastases (hazard ratio 6.9, P<0.001) within the first 3 years. This study determined patients with ciliary body involvement to be candidates for future adjuvant therapeutic interventions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0959-8049
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2389-95
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Independent prognostic factors for distant metastases and survival in patients with primary uveal melanoma.
pubmed:affiliation
Department of Medicine III (Hematology, Oncology and Transfusionmedicine), Charité, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany. alexander.schmittel@charite.de
pubmed:publicationType
Journal Article