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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5A
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pubmed:dateCreated |
2004-11-2
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pubmed:abstractText |
We previously reported that upregulation of glucuronidation activity catalyzed by uridine 5'diphosphoglucuronosyltransferase (UGT) is one of the mechanisms associated with irinotecan hydrochloride/7-ethyl-10-hydroaxycamptothecin (CPT-11/SN-38) resistance. In order to extend this result to the clinical setting, it is important to elucidate the role of SN-38 glucuronidation by UGT1A isoforms in CPT-11/SN-38 resistance in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2893-6
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pubmed:dateRevised |
2007-9-25
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pubmed:meshHeading |
pubmed-meshheading:15517893-Aged,
pubmed-meshheading:15517893-Aged, 80 and over,
pubmed-meshheading:15517893-Animals,
pubmed-meshheading:15517893-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:15517893-COS Cells,
pubmed-meshheading:15517893-Camptothecin,
pubmed-meshheading:15517893-Cercopithecus aethiops,
pubmed-meshheading:15517893-Chromatography, High Pressure Liquid,
pubmed-meshheading:15517893-Drug Resistance, Neoplasm,
pubmed-meshheading:15517893-Female,
pubmed-meshheading:15517893-Gene Expression,
pubmed-meshheading:15517893-Glucuronides,
pubmed-meshheading:15517893-Glucuronosyltransferase,
pubmed-meshheading:15517893-Humans,
pubmed-meshheading:15517893-Lung Neoplasms,
pubmed-meshheading:15517893-Male,
pubmed-meshheading:15517893-Middle Aged
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pubmed:articleTitle |
UGT1A10 is responsible for SN-38 glucuronidation and its expression in human lung cancers.
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pubmed:affiliation |
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. t-oguri@med.nagoya-cu.ac.jp
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pubmed:publicationType |
Journal Article
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