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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-1-19
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pubmed:abstractText |
Increasing evidence has suggested that oxidative stress may be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). The antioxidant vitamin E (alpha-tocopherol) has been shown to slow down the onset and progression of the paralysis in transgenic mice expressing a mutation in the superoxide dismutase gene found in certain forms of familial ALS. The current study, a double blind, placebo-controlled, randomised, stratified, parallel-group clinical trial, was designed to determine whether vitamin E (5000 mg per day) may be efficacious in slowing down disease progression when added to riluzole.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0300-9564
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pubmed:author |
pubmed-author:BeckerGG,
pubmed-author:DenglerRR,
pubmed-author:EckelJJ,
pubmed-author:EgerKK,
pubmed-author:GerlachMM,
pubmed-author:German vitamin E/ALS Study Group,
pubmed-author:GrafMM,
pubmed-author:HagenOO,
pubmed-author:HechtMM,
pubmed-author:HorowskiRR,
pubmed-author:JostW HWH,
pubmed-author:KUHNR BRB,
pubmed-author:KostopulosPP,
pubmed-author:KramerBB,
pubmed-author:KrampflKK,
pubmed-author:LubinVV,
pubmed-author:LudolphA CAC,
pubmed-author:NeudeckerSS,
pubmed-author:NeundörferBB,
pubmed-author:OsterhageJJ,
pubmed-author:PetriSS,
pubmed-author:RiedererPP,
pubmed-author:SchimkeNN,
pubmed-author:SchraderCC,
pubmed-author:SchrankBB,
pubmed-author:SievertMM,
pubmed-author:SteinCC,
pubmed-author:TraufellerKK,
pubmed-author:TroegerMM,
pubmed-author:WekwerthKK,
pubmed-author:WuerzAA,
pubmed-author:ZierzSS
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pubmed:issnType |
Print
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
649-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15517433-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:15517433-Dose-Response Relationship, Drug,
pubmed-meshheading:15517433-Female,
pubmed-meshheading:15517433-Humans,
pubmed-meshheading:15517433-Male,
pubmed-meshheading:15517433-Middle Aged,
pubmed-meshheading:15517433-Neuroprotective Agents,
pubmed-meshheading:15517433-Riluzole,
pubmed-meshheading:15517433-Treatment Outcome,
pubmed-meshheading:15517433-Vitamin E,
pubmed-meshheading:15517433-Vitamins
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pubmed:year |
2005
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pubmed:articleTitle |
High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study.
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pubmed:affiliation |
michael.graf@psl.ap-hop-paris.fr
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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