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rdf:type |
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lifeskim:mentions |
umls-concept:C0014609,
umls-concept:C0017349,
umls-concept:C0018133,
umls-concept:C0033684,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205263,
umls-concept:C0226890,
umls-concept:C1268930,
umls-concept:C1280500,
umls-concept:C1704222
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pubmed:issue |
2
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pubmed:dateCreated |
1992-4-28
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pubmed:abstractText |
The induction of major histocompatibility complex (MHC) class II expression in the epithelium of the small intestine of the rat during graft-versus-host disease (GVHD) and the effect of this process on the capacity of isolated epithelial cells to present antigen has been investigated. By immunohistology, increased class II (I-A) was noted in lamina propria cells and villus epithelium and de novo expression in crypt epithelium by Day 7 after transfer of parental spleen cells into irradiated hybrid rats. This increased expression reached a maximum by Day 9 or 10. The kinetics of induction of I-E products paralleled those of I-A in villus epithelium, but I-E was not seen in crypt epithelium. Direct radioimmunoassay of class II in isolated villus and crypt epithelial cells revealed a minor peak of class II, particularly in villus cells, very soon after cell transfer which waned and then increased to a second peak at Days 7-9. Assay of presentation of ovalbumin by isolated enterocytes to primed T cells at the peak of class II induction showed that increased class II expression by villus cells mediated enhanced antigen-presenting activity, whereas increases in crypt cell class II did not enable these cells to present ovalbumin.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-1690608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-1903764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-2140388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-2210870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-2230136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-2351304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-2423435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-2423441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-2514139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-2960770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-3146453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-3151441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-315315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-3335977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-3486193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-3500504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-3514010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-3558865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-3758613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-4055083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-6178598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-6217272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-6310611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-6425398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-6577996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-7022229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1551699-7030531
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
366-71
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1551699-Animals,
pubmed-meshheading:1551699-Antigen-Presenting Cells,
pubmed-meshheading:1551699-Cell Division,
pubmed-meshheading:1551699-Epithelium,
pubmed-meshheading:1551699-Female,
pubmed-meshheading:1551699-Gene Expression,
pubmed-meshheading:1551699-Genes, MHC Class II,
pubmed-meshheading:1551699-Graft vs Host Disease,
pubmed-meshheading:1551699-Intestine, Small,
pubmed-meshheading:1551699-Kinetics,
pubmed-meshheading:1551699-Male,
pubmed-meshheading:1551699-Rats,
pubmed-meshheading:1551699-Rats, Inbred Strains,
pubmed-meshheading:1551699-T-Lymphocytes
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pubmed:year |
1992
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pubmed:articleTitle |
Induction of MHC class II gene products in rat intestinal epithelium during graft-versus-host disease and effects on the immune function of the epithelium.
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pubmed:affiliation |
Department of Veterinary Medicine, University of Bristol, Langford, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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