Source:http://linkedlifedata.com/resource/pubmed/id/15516930
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2004-11-26
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pubmed:abstractText |
Splice acceptors with the genomic NAGNAG motif may cause NAG insertion-deletions in transcripts, occur in 30% of human genes and are functional in at least 5% of human genes. We found five significant biases indicating that their distribution is nonrandom and that they are evolutionarily conserved and tissue-specific. Because of their subtle effects on mRNA and protein structures, these splice acceptors are often overlooked or underestimated, but they may have a great impact on biology and disease.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1061-4036
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1255-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15516930-Alternative Splicing,
pubmed-meshheading:15516930-Animals,
pubmed-meshheading:15516930-Base Sequence,
pubmed-meshheading:15516930-Databases, Nucleic Acid,
pubmed-meshheading:15516930-Genetic Variation,
pubmed-meshheading:15516930-Genomics,
pubmed-meshheading:15516930-Humans,
pubmed-meshheading:15516930-Mutation,
pubmed-meshheading:15516930-Proteome,
pubmed-meshheading:15516930-RNA Splice Sites
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pubmed:year |
2004
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pubmed:articleTitle |
Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity.
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pubmed:affiliation |
Institute of Computer Science, Friedrich-Schiller-University Jena, Chair for Bioinformatics, Ernst-Abbe-Platz 2, 07743 Jena, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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