| pubmed-article:15516924 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15516924 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:15516924 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:15516924 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:15516924 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:15516924 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15516924 | pubmed:dateCreated | 2004-11-19 | lld:pubmed |
| pubmed-article:15516924 | pubmed:abstractText | Helper T cell differentiation involves silencing as well as activation of gene expression. We have identified a conserved silencer of the gene encoding interleukin 4 (Il4) marked by DNase I hypersensitivity (HS IV) and permissive chromatin structure in all helper T cells. Deletion of HS IV increased Il4 and Il13 transcription by naive T cells and led to T helper type 2 skewing in vitro. HS IV controlled Il4 silencing during T helper type 1 differentiation, as HS IV-deficient T helper type 1 cells that expressed interferon-gamma also produced abundant interleukin 4 in vitro and in vivo. Despite mounting a vigorous interferon-gamma response, HS IV-deficient mice were more susceptible to Leishmania major infection than were wild-type littermate control mice, showing a critical function for Il4 silencing in T helper type 1-mediated immunity. | lld:pubmed |
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| pubmed-article:15516924 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15516924 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15516924 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15516924 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15516924 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:15516924 | pubmed:author | pubmed-author:AltFrederick... | lld:pubmed |
| pubmed-article:15516924 | pubmed:author | pubmed-author:RaoAnjanaA | lld:pubmed |
| pubmed-article:15516924 | pubmed:author | pubmed-author:GreenwaldRebe... | lld:pubmed |
| pubmed-article:15516924 | pubmed:author | pubmed-author:SharpeArlene... | lld:pubmed |
| pubmed-article:15516924 | pubmed:author | pubmed-author:AnselK MarkKM | lld:pubmed |
| pubmed-article:15516924 | pubmed:author | pubmed-author:BassingCraig... | lld:pubmed |
| pubmed-article:15516924 | pubmed:author | pubmed-author:MonticelliSil... | lld:pubmed |
| pubmed-article:15516924 | pubmed:author | pubmed-author:LeeDong UDU | lld:pubmed |
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| pubmed-article:15516924 | pubmed:author | pubmed-author:DjureticIvana... | lld:pubmed |
| pubmed-article:15516924 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15516924 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:15516924 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15516924 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15516924 | pubmed:pagination | 1251-9 | lld:pubmed |
| pubmed-article:15516924 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15516924 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15516924 | pubmed:articleTitle | Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. | lld:pubmed |
| pubmed-article:15516924 | pubmed:affiliation | Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:15516924 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15516924 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15516924 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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