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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2004-11-19
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pubmed:abstractText |
Helper T cell differentiation involves silencing as well as activation of gene expression. We have identified a conserved silencer of the gene encoding interleukin 4 (Il4) marked by DNase I hypersensitivity (HS IV) and permissive chromatin structure in all helper T cells. Deletion of HS IV increased Il4 and Il13 transcription by naive T cells and led to T helper type 2 skewing in vitro. HS IV controlled Il4 silencing during T helper type 1 differentiation, as HS IV-deficient T helper type 1 cells that expressed interferon-gamma also produced abundant interleukin 4 in vitro and in vivo. Despite mounting a vigorous interferon-gamma response, HS IV-deficient mice were more susceptible to Leishmania major infection than were wild-type littermate control mice, showing a critical function for Il4 silencing in T helper type 1-mediated immunity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1529-2908
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pubmed:author |
pubmed-author:AgarwalSuneetS,
pubmed-author:AltFrederick WFW,
pubmed-author:AnselK MarkKM,
pubmed-author:BassingCraig HCH,
pubmed-author:DjureticIvana MIM,
pubmed-author:GreenwaldRebecca JRJ,
pubmed-author:InterlandiJeneenJ,
pubmed-author:LeeDong UDU,
pubmed-author:MonticelliSilviaS,
pubmed-author:RaoAnjanaA,
pubmed-author:SharpeArlene HAH
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1251-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15516924-Animals,
pubmed-meshheading:15516924-Cell Differentiation,
pubmed-meshheading:15516924-Cells, Cultured,
pubmed-meshheading:15516924-Chromatin,
pubmed-meshheading:15516924-Conserved Sequence,
pubmed-meshheading:15516924-Cytokines,
pubmed-meshheading:15516924-Deoxyribonuclease I,
pubmed-meshheading:15516924-Gene Expression Regulation,
pubmed-meshheading:15516924-Gene Silencing,
pubmed-meshheading:15516924-Genetic Predisposition to Disease,
pubmed-meshheading:15516924-Interleukin-4,
pubmed-meshheading:15516924-Leishmania major,
pubmed-meshheading:15516924-Leishmaniasis, Cutaneous,
pubmed-meshheading:15516924-Mice,
pubmed-meshheading:15516924-Mice, Knockout,
pubmed-meshheading:15516924-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:15516924-Sequence Deletion,
pubmed-meshheading:15516924-Th1 Cells,
pubmed-meshheading:15516924-Th2 Cells
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pubmed:year |
2004
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pubmed:articleTitle |
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity.
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pubmed:affiliation |
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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