Linked Life Data

15516222

Source:http://linkedlifedata.com/resource/pubmed/id/15516222

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 2
pubmed:dateCreated
2004-11-1
pubmed:abstractText
Histopathological heterogeneity in cancer is a general concern. Breast carcinoma heterogeneity is now widely admitted as a source of histological grading imprecision and reproducibility problems. Classically, homogeneity is defined as equivalent to stationarity. A measure of heterogeneity based on asymptotic properties of spatial statistics is developed. Long-range dependences in heterogeneous spatial processes make estimation of the proposed heterogeneity measure unreliable. A robust estimator based on the wavelet transform is presented; this bypasses long-range dependences. The estimator extends previous works on one-dimensional stochastic processes to two dimensions as appropriate for histopathological analysis. As a side result, the estimator gives confidence intervals for the heterogeneity measure that enables the formulation and validation of testable hypothesis on the observed histopathological samples. This approach is applied to the characterization of breast cancer tumours. We show that the heterogeneity measure for various blocks of a single tumour is invariable, even when various blocks differ in size and in number of marked nuclei.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-2720
pubmed:author
pubmed:issnType
Print
pubmed:volume
216
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
110-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Index for spatial heterogeneity in breast cancer.
pubmed:affiliation
Laboratoire d'Analyse d'Images en Pathologie Cellulaire, Institut Universitaire d'Hématologie, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France. sharifi@chu-stlouis.fr
pubmed:publicationType
Journal Article, Comparative Study