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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-4-11
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pubmed:abstractText |
Gene transfer to salivary glands (SGs) can be accomplished in a minimally invasive manner, resulting in stable, long-term secretion of the transgene product. Therefore, SGs provide a novel target site for several potentially useful clinical gene therapeutics applications. Previous studies have indicated that intravenous, intramuscular and intranasal administration of recombinant adeno-associated virus serotype 2 (rAAV2) vectors induce host immune responses. There are no reported studies on immune responsiveness of rAAV2 vector administration to SGs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1099-498X
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pubmed:author |
pubmed-author:BaumBruce JBJ,
pubmed-author:BossisIoannisI,
pubmed-author:ChioriniJohn AJA,
pubmed-author:CotrimAnaA,
pubmed-author:KatanoHisakoH,
pubmed-author:KokMarc RMR,
pubmed-author:ParrotPP,
pubmed-author:TranSimon DSD,
pubmed-author:VoutetakisAntonisA,
pubmed-author:WangJianghuaJ,
pubmed-author:YamanoSeiichiS
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pubmed:copyrightInfo |
Copyright (c) 2004 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
432-41
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15515118-Animals,
pubmed-meshheading:15515118-Cell Line,
pubmed-meshheading:15515118-Dependovirus,
pubmed-meshheading:15515118-Genetic Vectors,
pubmed-meshheading:15515118-Humans,
pubmed-meshheading:15515118-Immunity, Innate,
pubmed-meshheading:15515118-Immunohistochemistry,
pubmed-meshheading:15515118-Male,
pubmed-meshheading:15515118-Mice,
pubmed-meshheading:15515118-Mice, Inbred BALB C,
pubmed-meshheading:15515118-Polymerase Chain Reaction,
pubmed-meshheading:15515118-Recombination, Genetic,
pubmed-meshheading:15515118-Salivary Glands
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pubmed:year |
2005
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pubmed:articleTitle |
Immune responses following salivary gland administration of recombinant adeno-associated virus serotype 2 vectors.
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pubmed:affiliation |
Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA. m.r.kok@amc.uva.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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