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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-10-29
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pubmed:abstractText |
Beta-arrestins play a pivotal role in G protein-coupled receptor desensitization. beta-Arrestins interfere in G protein receptor interaction, thus leading to desensitization of G protein-mediated receptor signaling. G protein receptor signaling and its desensitization were previously implicated in the pathophysiology of mood disorders and in the mechanism of action of antidepressant and mood-stabilizing treatments. The present study aims at quantitatively evaluating beta-arrestin-1 levels in leukocytes of patients with major depression and the effect of antidepressants on beta-arrestin-1 levels in rat brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0002-953X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
161
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2066-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15514408-Adult,
pubmed-meshheading:15514408-Aged,
pubmed-meshheading:15514408-Animals,
pubmed-meshheading:15514408-Antidepressive Agents,
pubmed-meshheading:15514408-Arrestins,
pubmed-meshheading:15514408-Brain Chemistry,
pubmed-meshheading:15514408-Cerebral Cortex,
pubmed-meshheading:15514408-Corpus Striatum,
pubmed-meshheading:15514408-Depressive Disorder,
pubmed-meshheading:15514408-Desipramine,
pubmed-meshheading:15514408-Down-Regulation,
pubmed-meshheading:15514408-Female,
pubmed-meshheading:15514408-Fluvoxamine,
pubmed-meshheading:15514408-Hippocampus,
pubmed-meshheading:15514408-Humans,
pubmed-meshheading:15514408-Imipramine,
pubmed-meshheading:15514408-Leukocytes, Mononuclear,
pubmed-meshheading:15514408-Male,
pubmed-meshheading:15514408-Middle Aged,
pubmed-meshheading:15514408-Psychiatric Status Rating Scales,
pubmed-meshheading:15514408-Rats,
pubmed-meshheading:15514408-Rats, Sprague-Dawley,
pubmed-meshheading:15514408-Receptors, G-Protein-Coupled,
pubmed-meshheading:15514408-Severity of Illness Index
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pubmed:year |
2004
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pubmed:articleTitle |
Beta-arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain.
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pubmed:affiliation |
Department of Clinical Pharmacology, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, ISRAEL. sofia@bgumail.bgu.ac.il
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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